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Tohru Sugawara

As seen in: Journal of Medical Genetics (JMG), Cell Press
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Articles by Tohru Sugawara

Congenital anaemia associated with loss-of-function variants in DNA polymerase epsilon 1

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By Ichiro Takeuchi, Kanako Tanase-Nakao, Ayame Ogawa, Tohru Sugawara
| Journal of Medical Genetics (JMG)
Genotype-phenotype correlations Congenital anaemia associated with loss-of-function variants in DNA polymerase epsilon 1 Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
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Congenital anaemia associated with loss-of-function variants in DNA polymerase epsilon 1

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By Ichiro Takeuchi, Tohru Sugawara, Kanako Tanase-Nakao, Ayame Ogawa
| Journal of Medical Genetics (JMG)
Genotype-phenotype correlations Congenital anaemia associated with loss-of-function variants in DNA polymerase epsilon 1 Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Open in Who Shared Issue with article?

Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis

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By Seiji Ogawa, Mitsutoshi Yamada, Akihiro Nakamura, Tohru Sugawara
| Cell Press Verified
Highlights • Deficiency of zygotic genome activation gene Zscan5b causes chromosomal anomalies • Zscan5b binds to linker histone H1 and protects chromosomal structure • Irradiated Zscan5b-deficient ESCs show significantly increased DNA stress markers • Zscan5b-deficient ESCs develop small choriocarcinomas and embryonal carcinomas Summary Zygotic genome activation (ZGA) begins after fertilization and is essential for establishing pluripotency and genome stability.
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