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Chemical Proteomics-based Target Prioritization through a Residue Agnostic Ligandability Assessment Platform

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By Raiyan Chowdhury, Rebecca Allan, Fettah Erdogan, Tom Bobby Chandy
| chemrxiv.org
Abstract The landscape of drug discovery is undergoing a transformative phase with the influx of structural biology and omics data. Identifying optimal drug targets amid this data surge presents a multifaceted challenge. Covalent inhibitors, once undervalued, now hold substantial promise, especially targeted covalent inhibitors (TCIs), effectively engaging 'undruggable' proteins and overcoming resistance mechanisms.
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