Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Abstract To elucidate the genetic architecture of the DNA damage response (DDR) network, we conduct unbiased genetic interaction screens using Cas12a. We disrupt 233 DDR genes frequently mutated in cancer and other genetic diseases, either individually or in pairwise combinations, enabling us to assess the phenotypic effects induced by the loss of DDR gene pairs under unperturbed cell growth conditions.
Abstract In budding yeast, the integrity of both the nuclear and mitochondrial genomes relies on dual-targeted isoforms of the conserved Pif1 helicase, generated by alternative translation initiation (ATI) of PIF1 mRNA from two consecutive AUG codons flanking a mitochondrial targeting signal. Here, we demonstrate that ribosomal leaky scanning is the specific ATI mechanism that produces not only these, but also novel, previously uncharacterized Pif1 isoforms.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
