Tomaz Mesar

T.Mesar, A.Jackson, G.Chachati, et al., “The Impact of Vascular Access Complications in Patients Undergoing Transcatheter Aortic Valve Replacement,” Catheterization and Cardiovascular Interventions0 (2026): 1–10, https://doi.org/10.1002/ccd.70560. Conflicts of Interest I.S. receives institutional funding and consults for Abbott, Artivion, Atricure, Edwards Lifesciences, Medtronic, and Terumo Aortic. The other authors declare no conflicts of interest.

In Reply We thank Launey et al for their insightful comments in response to our recently published retrospective analysis of the ratio of fresh frozen plasma to red blood cells during massive transfusions in nontrauma patients.1 As they point out, the use of antifibrinolytic agents, such as tranexemic acid (TXA), is well established in cardiac surgery and has been demonstrated to be safe and effective in trauma patients and during postpartum hemorrhage.2,3 Indeed, TXA is already included in...

Key Points Question Is hemostatic resuscitation being practiced for rapidly bleeding patients without trauma? Findings In this retrospective study of 865 massive transfusion events in an urban academic hospital, nearly 90% of all massive transfusions were received by patients without trauma, but there was no evidence that a ratio-based transfusion strategy of high fresh frozen plasma to red blood cells ratio improved survival.