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Los neutrófilos se han descrito tradicionalmente como células inflamatorias esenciales para la defensa inmunitaria frente a infecciones. Sin embargo, estudios recientes han cambiado esta visión, revelando que los neutrófilos infiltran tejidos en condiciones de homeostasis y se especifican funcionalmente para apoyar distintos contextos fisiológicos (Ballesteros et al. 2020; Casanova-Acebes et al. 2018).
Highlights • Neutrophils have variable lifetimes in tissues • Neutrophils acquire distinct phenotypic and functional properties in tissues • Tissue-derived signals drive rapid adaptation of neutrophils • Neutrophil reprogramming in the lungs occurs in CXCL12+ niches. Summary Classically considered short-lived and purely defensive leukocytes, neutrophils are unique in their fast and moldable response to stimulation.
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