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Tommy Weiss-Sadan

As seen in: Cell Metabolism
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Articles

NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer

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By Tommy Weiss-Sadan, Maolin Ge, Makiko Hayashi, Magdy Gohar
| Cell Metabolism Verified
A subset of lung cancer cell lines is sensitive to activation of the transcription factor NRF2. The metabolic state of a cancer cell dictates sensitivity to NRF2, whose activation results in a NADH/NAD+ imbalance. As a result, the blockade of mitochondrial Complex I is a synthetic lethality in NRF2-activated lung cancers.
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NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer

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By Tommy Weiss-Sadan, Maolin Ge, Makiko Hayashi, Magdy Gohar
| Cell Metabolism Verified
Kerk S.A. Papagiannakopoulos T. Shah Y.M. Lyssiotis C.A. Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment. Nat. Rev. Cancer. 2021; 21: 510-525https://doi.org/10.1038/s41568-021-00375-9 Martínez-Reyes I. Chandel N.S. Cancer metabolism: looking forward. Nat. Rev. Cancer. 2021; 21: 669-680https://doi.org/10.1038/s41568-021-00378-6 Cantor J.R. Sabatini D.M. Cancer cell metabolism: one hallmark, many faces. Cancer Discov.
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By Yael Ben-Nun, Emmanuelle Merquiol, Karen Meir, Ilan Matok, Rachela Popovtzer, Darya Tsvirkun, Ivan Zlotver, Tommy Weiss-Sadan, Galia Blum
| American Chemical Society
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