Tomohiro Masuda

ArticleOnline now102831Open access Affiliations & Notes 1Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan 2Research Center, Kobe City Eye Hospital, Kobe, Hyogo 650-0047, Japan 3Department of Ophthalmology Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan 4Department of Molecular and Cellular Biology, Scripps Research, La Jolla, CA 92037, USA 5Omics AI Research Team, Advanced General Intelligence in...

Highlights • We enriched RPCs using LF-GC • LF-GC-based-sorted RPCs consistently developed retinal tissues for transplantation • LF-GC-based sorting achieved nearly 10 times efficiency in retinal graft preparation • LF-GC-enriched hiPSC-RPC grafts structurally matured in retinal degeneration animals Summary Pluripotent stem cell-based therapy for retinal degenerative diseases is a promising approach to restoring visual function.

Highlights • hESC- and iPSC-retinas poorly express HLA molecules • hESC- and iPSC-retinas have immunosuppressive properties • hESC- and iPSC-retinas can suppress allogeneic lymphocytes • hESC- and iPSC-retinas suppress immune cells via TGF-β signaling Summary ESC- and iPSC-derived retinal transplantation is a promising therapeutic approach for disease with end-stage retinal degeneration, such as retinitis pigmentosa and age-related macular degeneration.