Tomoyasu Matsubara

1 Introduction Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are closely related neurodegenerative disorders that may exhibit clinical overlap: 15% of patients with ALS develop FTD and 12%–14% of those with FTD develop ALS during their clinical course [1-3]. Variants in the TANK-binding kinase 1 (TBK1) gene are associated with FTD and/or ALS (FTDALS4; OMIM #616439), making TBK1 a major genetic contributor to the FTD–ALS spectrum alongside C9orf72.

Correction to: Nature https://doi.org/10.1038/s41586-020-2317-6 Published online 27 May 2020 In the version of the article initially published, the “DLB Case 1” image in Extended Data Fig. 7 was a duplicate of the “MSA case 1, Cerebellum” image in Extended Data Fig. 1. Extended Data Fig. 7 has now been amended to include the correct “DLB Case 1” image in the HTML and PDF versions of the article. About this article Schweighauser, M., Shi, Y., Tarutani, A. et al.

ALS amyotrophic lateral sclerosis BBAR brain bank for aging research FALS familial ALS GFAP glial fibrillary acidic protein MRI magnetic resonance imaging NCIs neuronal cytoplasmic inclusions PCR polymerase chain reaction pTDP-43 phosphorylated TDP-43 TDP-43 transactivation response DNA-binding protein 43 kDa Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting both upper and lower motor neurones, characterised by intracytoplasmic inclusions of...