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Tone-Kari K. Østbye on Muck Rack

Tone-Kari K. Østbye

As seen in: BioRxiv
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Articles

Herring roe PLs promote SPM biosynthesis in macrophages and a keratinocyte/fibroblast co-culture as model of psoriasis

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By Thomas A. Ringheim-Bakka, Amitis Saliani, Tone-Kari K. Østbye
| BioRxiv
Abstract Psoriasis is a chronic immune-mediated inflammatory disease (IMID) affecting the skin presenting with both local and systemic inflammation as part of its pathophysiology. An oil rich in phospholipids extracted from herring roe has been shown to have immunomodulatory properties and to improve clinical symptoms and impact inflammatory cytokine pathways in psoriasis in a clinical trial.
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Phospholipid esters from herring roe promotes SPM biosynthesis in human monocyte-derived macrophages and a keratinocyte/fibroblast co-culture with implications for the treatment of psoriasis

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By Amitis Saliani, Jennifer Mildenberger, Thomas A. Ringheim-Bakka, Tone-Kari K. Østbye
| BioRxiv
Abstract Immune-mediated inflammatory disease (IMID) is a major public health issue which can affect a number of organs and tissues with a profound impact on quality of life and often present with comorbidities. Psoriasis is a chronic IMID affecting the skin which presents with both local and systemic inflammation as part of its pathophysiology.
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