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Tony Barbay

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Articles

Signaling cascades shape functional subpopulations of cortical astrocytes in male wild-type mice and APP/PS1dE9 Alzheimer’s disease model

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By Vivien Letenneur, Céline Derbois, Martine Guillermier, Miriam Riquelme-Perez, Fanny Petit, Alexis-Pierre Bemelmans, Rémi Bos, Maria-Angeles Carrillo-de Sauvage, Giampaolo Milior, Nathalie Rouach, Kévin Muret, Eric Bonnet Verified, Carole Escartin, Yiannis Poulot-Becq-Giraudon, Océane Guillemaud, Elisa Degl’Innocenti, Karouna Bascarane, Tony Barbay, Mie Møller Clausen, Ludmila Juricek, Tom Lakomy, Lucile Benhaim, Noëlle Dufour, Pauline Gipchtein, Léa Siron, Gwennaëlle Aurégan, Nathalie Dechamps, Marie-Claude Gaillard, Solène Brohard
| Nature Verified
Abstract Astrocytes are key partners for neurons and can impact diseases such as Alzheimer’s disease (AD), as they exhibit multiple reactive changes. Recent single cell/nucleus genomics analyses evidence astrocyte subpopulations coexisting in normal and AD brains. However, the signaling cascades controlling them, their functional characteristics and roles in AD are still unknown.
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