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Tooyib A Azeez on Muck Rack

Tooyib A Azeez

As seen in: Wiley Online Library, BioRxiv, Physiological Research
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Articles

Chronic administration of the hydrogen sulfide prodrug SG1002 partially protects against erectile dysfunction resulting from long-term androgen deprivation

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By Colin M. Ihrig, Clifford J. Pierre, Tooyib A Azeez
| BioRxiv
Abstract Aims: Androgen deprivation therapy is a common treatment strategy for prostate cancer, although erectile dysfunction (ED) often coincides as an undesirable side-effect. Hydrogen sulfide (H2S) is an endogenous gasotransmitter with vasodilatory, anti-inflammatory, and antioxidant-like properties. H2S therapies are being developed for cardiovascular disease management, although the properties of H2S may also protect the erectile system.
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Cystathionine γ Lyase Deletion Enhances Corpus Cavernosum Contraction via Thromboxane A2 and Neurogenic Pathways Without Affecting Endothelial Function

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By Tooyib A Azeez, Clifford J. Pierre, Colin M. Ihrig, Stephen Chelko
| BioRxiv
Abstract Cystathionine γ-lyase (CSE) produces hydrogen sulfide (H₂S), a vasodilator critical for vascular function. While its systemic effects are well-documented, its role in erectile physiology remains unclear. This study investigated the impact of CSE deletion on vascular and erectile tissue reactivity. We hypothesized that CSE knockout (CSE-KO) mice would exhibit endothelial dysfunction. A total of 22 CSE-KO and 22 age-matched wild-type (WT) controls were studied at one year of age.
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Hydrogen sulfide protects erectile function through stimulation of antioxidant defense in the corpus cavernosum

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By Tooyib A Azeez, Clifford J. Pierre, Paige R. Rhein, Colin M. Ihrig
| BioRxiv
Abstract Obesity is a major risk factor for erectile dysfunction, whereby excess reactive oxygen species (ROS) in the corpus cavernosum have been implicated as a causative factor. Hydrogen sulfide (H2S) is an endogenous gasotransmitter with vasodilatory and antioxidant properties. The objectives of this study were to determine the influence of H2S on erectile function, penile ROS, and expressions of endogenous antioxidant genes and proteins in the corpus cavernosum.
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