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Toshiya Nishi on Muck Rack

Toshiya Nishi

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Articles

KCC2 activation during postnatal development alleviates long-term deficits in CDKL5-deficient mice - Experimental & Molecular Medicine

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By Muhammad Arshad, Christopher Bope, Noell Cho, Jacob S Dengler, Joshua Smalley, Toshiya Nishi, Zhong Zhong, Stephen Moss, Paul A. Davies
| Nature Verified
Abstract Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a severe developmental and epileptic encephalopathy characterized by early onset drug-resistant seizures and later cognitive and social impairments. Existing therapies primarily involve antiseizure medications, which have sedative side effects and lack effective treatments for behavioral impairments.
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