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Tovia Jacobs

As seen in: Nature, BioRxiv
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Articles

White matter microstructure differences in obstructive sleep apnea severity groups assessed by diffusion tensor metrics and biophysical modeling - Scientific Reports

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By Luisa F. Figueredo, Jenny Chen, Naomi Gaggi, Xiaotong Song, Tovia Jacobs, Shayna Pehel, Moses Gonzalez, Ivana Rosenzweig, Sharon L. Naismith, Jaime Ramos-Cejudo, Joshua Gills, Indu A. Ayappa, David M. Rapoport, Korey Kam, Anna E. Mullins, Ankit Parekh, Andrew W. Varga, Omonigho M. Bubu, Esther M. Blessing, Dmitry S. Novikov, Els Fieremans, Ricardo S. Osorio, Gabriela Silva-Albornoz, Sandra Giménez Badia
| Nature Verified
Abstract Obstructive sleep apnea (OSA) is a complex condition characterized by repeated episodes of upper airway collapse during sleep, leading to chronic intermittent hypoxia. Diffusion magnetic resonance imaging (dMRI) techniques offer sensitivity to white matter (WM) microstructure changes. 150 individuals from a community-based study underwent one-night nocturnal polysomnography (NPSG), cognitive assessments, and brain structural MRI.
Open in Who Shared Issue with article?

Elucidating the neuropathological and molecular heterogeneity of amyloid-beta and tau in Alzheimer's disease through machine learning and transcriptomic integration

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By Kanhao Zhao, Hua Xie, Naomi Gaggi, Tovia Jacobs
| BioRxiv
Abstract Discerning functional brain network variations related to neuropathological aggregates in Alzheimer's disease (AD), including amyloid-beta (Abeta) and phosphorylated tau (p-tau), is crucial for understanding their link to cognitive decline and underlying molecular mechanisms. However, these variations are often confounded by normal aging-related changes, complicating interpretation.
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