Tracy-Ann Read

Abstract Angiogenesis is essential for development and tissue repair after ischemia. Reactive oxygen species (ROS) act as signaling molecules that promote angiogenesis in endothelial cells (ECs) which mainly rely on aerobic glycolysis for energy production. However, how redox signaling couples to endothelial metabolism remains unclear. Here, we identify endothelial Drp1 as a redox sensor that links VEGF-induced H₂O₂ signaling to metabolic reprogramming and angiogenesis.

1 INTRODUCTION Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscle weakness and premature degeneration of upper and lower motor neurons. Median survival after symptom onset is 3–5 years, there is no cure, and what limited treatment options exist today have had minimal success (Saini & Chawla, 2024). Approximately 10% of ALS cases are linked to genetic mutations inherited within families (fALS) (Talbott et al., 2016).