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Travis Zeigler

As seen in: Frontiers in Immunology

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Articles

STING inhibits viral lytic reactivation and cell growth in primary effusion lymphoma

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By Amy Nguyen, Travis Zeigler, Kimberly Paulsen, Sumita Bhaduri- McIntosh, Zhe Ma, Cathrine Pacini, Alexa Ziff, Alayna Simpson
| Frontiers in Immunology
Abstract Kaposi’s sarcoma-associated herpesvirus (KSHV) is a DNA virus linked to multiple malignancies associated with compromised immunity, such as Kaposi’s sarcoma (KS) and primary effusion lymphoma (PEL). These malignancies are strongly linked to HIV coinfection and remain major oncogenic risks even with advanced antiretroviral therapy. Current treatments are limited and often non-curative, highlighting the need to define host pathways that constrain KSHV replication and tumor progression.
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