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Articles by Trever C. Smith
Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action
Abstract Treatments for tuberculosis remain lengthy, motivating a search for new drugs with novel mechanisms of action. However, it remains challenging to elucidate the direct targets of a drug, and even more so, to determine which disrupted cellular processes lead to bacterial killing.
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Morphological profiling of tubercle bacilli identifies drug pathways of action
Morphological profiling of tubercle bacilli identifies drug pathways of action Trever C. Smith, Krista M. Pullen, Michaela C. Olson, Morgan E. McNellis, Ian Richardson, Sophia Hu, Jonah Larkins-Ford, Xin Wang, Joel S. Freundlich, D. Michael Ando, Bree B. Aldridge Proceedings of the National Academy of Sciences Jul 2020, 202002738; DOI: 10.1073/pnas.2002738117
Targeting drugs for tuberculosis
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Borrelia Host Adaptation Protein (BadP) Is Required for the Colonization of a Mammalian Host by the Agent of Lyme Disease
Borrelia Host Adaptation Protein (BadP) Is Required for the Colonization of a Mammalian Host by the Agent of Lyme Disease
Borrelia Host Adaptation Protein (BadP) Is Required for the Colonization of a Mammalian Host by the Agent of Lyme Disease
Borrelia burgdorferi, the agent of Lyme disease (LD), uses host-derived signals to modulate gene expression during the vector and mammalian phases of infection. Microarray analysis of mutants lacking the Borrelia host adaptation regulator (BadR) revealed the downregulation of genes encoding enzymes whose role in the pathophysiology of B. burgdorferi is unknown.
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