Tribani Boruah

The transition from laboratory-scale electrochemical transformations to industrial production represents one of the most significant challenges in modern synthetic chemistry. (1,2) Despite the renaissance in organic electrosynthesis since 2000, with numerous elegant methodologies demonstrating remarkable selectivity and functional group tolerance, the practical implementation of these reactions at meaningful scales remains limited.

Introduction Click to copy section linkSection link copied! Thioether skeletons have appeared as cornerstone structural motifs in the design of drugs, pharmaceuticals, and materials. (1−3) The C–S–C linkage within diaryl thioether compounds improves lipophilicity, enhancing pharmacokinetic properties such as membrane permeability, which is highly desirable in drug development.

Flow Electrosynthesis of Phosphinamides and Phosphoramidates through P–N Coupling A robust flow electrochemical methodology operating under mild reaction conditions for P–N and P–O oxidative coupling has been developed. Potentiostatic and galvanostatic electrolysis were used to investigate reactant redox behaviour, showcasing a broad substrate scope (40 examples, up to 85% yield) across various chemical contexts. This article is Open Access This article has not yet been cited.