Trinset Weeraphan

1. Introduction Bioactive metabolites are mostly produced from various genera of actinomycetes, including members of Streptomyces, Actinomadura, Nonomuraea, Micromonospora, and Verrucosispora [1]. Streptomyces is the most important and dominant genus within the actinomycete groups. This genus belongs to the family Streptomycetaceae, which have a high G+C content in their DNA and form extensively branched substrate and aerial mycelia that later differentiate into spore chains [2].