Triveni Menon

Abstract Signaling pathways induce stereotyped transcriptional changes as stem cells progress into mature cell types during embryogenesis. Signaling perturbations are necessary to discover which genes are responsive or insensitive to pathway activity. However, gene regulation is additionally dependent on cell state-specific factors like chromatin modifications or transcription factor binding.

Abstract Haploid larvae in non-mammalian vertebrates are lethal with characteristic organ growth retardation collectively called "haploid syndrome." In contrast to mammals whose haploid intolerance is attributed to imprinting misregulation, the cellular principle of haploidy-linked defects in non-mammalian vertebrates remains unknown. Here, we investigated cellular defects that disrupt the ontogeny of gynogenetic haploid zebrafish larvae.

As the world segued into the year 2020, we were faced with a global challenge called COVID-19. As of 24 April 2020, there are over 27 lakh individuals infected with SARS-CoV-2 and nearly two lakh people have died worldwide. Like many other respiratory diseases caused by viral pathogens, COVID-19 cannot be diagnosed entirely based on the presentation of symptoms as they closely resemble symptoms of the common flu and are therefore not unique.