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Articles by Kevin Monahan
Recruitment of TEX15 by HUSH2 drives repression of multicopy gene families in fertility regulation
Abstract Chromatin-associated proteins are key regulators of fertility. While the testis-specific protein TEX15 and a HUSH2 component TASOR2 have established roles in early germ cells and somatic cells respectively, this study identifies their cooperative role during spermiogenesis. Postnatal loss of either TEX15 or TASOR2 in mice causes teratozoospermia without retrotransposon de-repression. Mechanistically, TEX15 complexes with TASOR2 but not its paralogue TASOR in the testis.
Kevin Monahan - CFO
Kevin Monahan - CFO. Profile, career history, and related news on Coincu.
Low-dose aspirin: effective cancer chemoprevention in Lynch syndrome
FREE with registration! Log in or register to access the full article. References 1. Burn, J ∙ Sheth, H ∙ Elliott, F ∙ et al. Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial Lancet. 2020; 395:1855-1863 2. Rothwell, PM ∙ Wilson, M ∙ Elwin, CE ∙ et al.
Mol005 LYNCH SYNDROME NETWORK CONSENSUS (LYNSYNC). INTERNATIONAL GUIDELINES ON CLINICAL MANAGEMENT, SURVEILLANCE, AND PREVENTION
On Behalf Of The LYNSYNC Group
Outcomes from the English National Lynch Syndrome transformation project
CONFLICT OF INTEREST STATEMENT David N. Church speaker fees GSK. David N. Church Other: spouse Amgen employee. *All unrelated to current manuscript. All other authors declare no conflict of interest. DATA AVAILABILITY STATEMENT The datasets generated and/or analysed during the current study are available from the corresponding author on reasonable request. Supporting Information Filename Description ijc70330-sup-0001-TableS1-S2.pdfPDF document, 52 KB TABLE S1.
2 dead, more than a dozen injured after Mexican naval training ship strikes Brooklyn Bridge Original
A Mexican Navy training ship is seen in front of the Manhattan Bridge, after it was damaged running into the Brooklyn Bridge in New York City, U.S., on May 17, 2025. Santiago Lyon | Reuters Two people died and more than a dozen others were injured when a historic Mexican naval training ship struck the Brooklyn Bridge in New York City on Saturday night, Mayor Eric Adams said.
Tall ship flying Mexican flag strikes Brooklyn Bridge, injuring several people Original
May 17, 2025, 10:27 PM EDT / Updated May 17, 2025, 10:29 PM EDT A tall ship flying the Mexican flag struck the Brooklyn Bridge in New York City Saturday night, seriously injuring at least three people, police sources with knowledge of the incident said. An additional dozen or so people suffered minor injuries, the officials said. Others were being checked out, and divers were probing waters at the scene as a precaution, according to the sources.
Ionizing Radiation May Induce Tumors Partly Through the Alteration or Regulation of Mismatch Repair Genes
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The race for clerk in a rural Michigan county has become a battle over 2020 election denialism Original
Oct. 28, 2024, 9:11 PM UTC BELLAIRE, Mich. — Sheryl Guy never dreamed she’d be thrust into a national political firestorm. “I was appalled,” she said. “I was betrayed, and I was used.” Guy, 63, is the Antrim County clerk in northwest Michigan. After a 45-year career working for the county from switchboard operator to clerk and everything in between, she had planned to retire after the 2024 election.
Carrier testing for partners of MUTYH variant carriers: UK Cancer Genetics Group recommendations
Carrier testing for partners of MUTYH variant carriers: UK Cancer Genetics Group recommendations Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Carrier testing for partners of MUTYH variant carriers: UK Cancer Genetics Group recommendations
Delivery of Health Care Digestive System Neoplasms DNA Repair Gastroenterology Genetic Carrier Screening MUTYH-associated polyposis (MAP) is an autosomal recessive condition caused by biallelic constitutional pathogenic variants in the MUTYH gene. MAP is associated with colonic polyposis (typically adenomas, but less commonly hyperplastic, serrated or mixed) and increased cancer (colorectal, duodenal and others) risk.
How a Texas hospital is fighting a condition that kills pregnant women
Several weeks into her second pregnancy, Bianca Chavarria knew something was wrong. The baby felt strangely heavy, and there was pressure in her abdomen. “It didn’t feel like my first pregnancy at all,” said Chavarria, then 20, of Floresville, Texas, just outside San Antonio. Chavarria said her doctors downplayed her symptoms, so she went online to do her own research.
Ex-Military Surgeons Want To Stop Americans From Bleeding to Death
Members of the “whole blood mafia” have used persuasion and persistence to increase the number of communities where rescue vehicles carry blood. Read Full Article » Show comments Hide Comments Related Articles
Ex-military surgeons embrace new mission: stop Americans from bleeding to death
A movement to revolutionize the treatment of trauma patients in the U.S. can be traced to an infamous battle fought in East Africa more than 30 years ago. Dr. John Holcomb was an Army trauma surgeon deployed to Somalia when two Black Hawk helicopters were shot down over the city of Mogadishu in 1993. With dozens of soldiers bleeding out and no hospitals available, the head doctor told Holcomb to prepare for a “walking blood bank.” “I had never heard of such a thing,” Holcomb recalled.
Extent of investigation and management of cases of ‘unexplained’ mismatch repair deficiency (u-dMMR): a UK Cancer Genetics Group consensus
Discussion The term LLS refers to an intermediate state of testing, and not a distinct heritable syndrome per se, and has therefore never been clearly defined despite advances in molecular testing and evaluation. Thus, some authors have suggested that the term may cause confusion and is redundant and should not be used.35 37 38 The consensus in this meeting was that the term ‘u-dMMR’ more accurately reflected intermediate and/or uncertainty in testing for dMMR cancers.
Why is the U.S. power grid so vulnerable during cold snaps?
In five of the past 11 years, parts of the U.S. electrical grid have been hit by blackouts, shut-offs or close calls during cold weather, according to an NBC News review of federal and state records and internal utility documents, with each major cold snap threatening a grid failure. Experts say one of the main culprits is a recurring shortage of natural gas, which became the main source of power for the electrical grid in 2016 and will carry more of the burden in coming years.
RNA-mediated symmetry breaking enables singular olfactory receptor choice - Nature
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Abstract Olfactory receptor (OR) choice provides an extreme example of allelic competition for transcriptional dominance, where every olfactory neuron stably transcribes one of approximately 2,000 or more OR alleles1,2. OR gene choice is mediated by a multichromosomal enhancer hub that activates transcription at a single OR3,4, followed by OR-translation-dependent feedback that stabilizes this choice5,6.
By Andrea M. Chiariello, Rachel Duffié, Kevin Monahan Verified, Alexa Osterhoudt, Job Dekker, Mario Nicodemi
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Nature
Verified
Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
eLife assessment This is an important paper that revises the canonical model of how olfactory sensory neurons choose which odor receptor to express. The data presented in the paper are convincing and the model proposed is provocative and likely to enable important future work. https://doi.org/10.7554/eLife.87445.3.sa0 About eLife assessments Introduction The development of multicellular organisms relies on gene expression programs that are precisely regulated in space and time.
Can a new early reading program help revive this poor Mississippi town?
LAMBERT, Miss. — When Evelyn Jossell took over as the superintendent of schools in Quitman County, she had no illusions about the challenges ahead. Poverty has long had a stranglehold on this rural, predominantly Black community in the Mississippi Delta.
Can a new early reading program help revive this poor Mississippi town?
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Can a new early reading program help revive this poor Mississippi town?
Create your free profile or log in to save this article Dec. 2, 2023, 2:00 PM UTC LAMBERT, Miss. — When Evelyn Jossell took over as the superintendent of schools in Quitman County, she had no illusions about the challenges ahead. Poverty has long had a stranglehold on this rural, predominantly Black community in the Mississippi Delta.
The English National Lynch Syndrome transformation project: an NHS Genomic Medicine Service Alliance (GMSA) programme
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JBJS
Results: Twenty-one RCTs evaluating the outcomes for 1,203 patients who had been treated with functional bracing (n = 190), ORIF (n = 479), MIPO (n = 177), aIMN (n = 312), or rIMN (n = 45) were included. Functional bracing yielded significantly higher odds of nonunion and significantly longer time to union than ORIF, MIPO, and aIMN (p < 0.05). Comparison of surgical fixation techniques demonstrated significantly faster time to union with MIPO than with ORIF (p = 0.043).
Lynch syndrome: from detection to treatment
1 Introduction Lynch Syndrome (LS) is a hereditary cancer predisposition syndrome characterised by a high lifetime risk of developing cancers, primarily colorectal and endometrial (1). These cancers exhibit microsatellite instability (MSI) due to defects in the cellular mismatch repair (MMR) system (2).
Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
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Paradise lost: Inside Peru's emergency zone
One afternoon in March, Zambrano, 75, was returning home from a trip to Puerto Maldonado, the capital city of Madre de Dios. It was about 1 p.m. when he pulled up to his front gate, got out of his car and took out his keys. Unbeknownst to Zambrano, a motorcycle had been tailing him with two men aboard. Zambrano said he didn’t hear the motorcycle come to a stop, and he didn’t see the man on the back of the bike pull out two guns and point them in his direction.
Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG)
Implementation We recommend that FIT, as a diagnostic triage tool, can be implemented safely at primary care level, and that a programme of education be developed to facilitate implementation of FIT in primary care. GRADE of evidence: very low; Strength of recommendation: Strong. Most studies of the use FIT in the symptomatic population are essentially studies of diagnostic accuracy.
Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG)
Implementation We recommend that FIT, as a diagnostic triage tool, can be implemented safely at primary care level, and that a programme of education be developed to facilitate implementation of FIT in primary care. GRADE of evidence: very low; Strength of recommendation: Strong. Most studies of the use FIT in the symptomatic population are essentially studies of diagnostic accuracy.
Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG)
Implementation We recommend that FIT, as a diagnostic triage tool, can be implemented safely at primary care level, and that a programme of education be developed to facilitate implementation of FIT in primary care. GRADE of evidence: very low; Strength of recommendation: Strong. Most studies of the use FIT in the symptomatic population are essentially studies of diagnostic accuracy.
Diagnosis and management of Lynch syndrome
Aspirin Meta-analyses by Rothwell et al assessing observational data among populations taking aspirin demonstrated an absolute risk reduction of 20% in all cancers; however, within GI cancers, the benefit was as much as 34% risk reduction, which was statistically significant. Notably, there is typically a ‘lag-period’ of approximately 7–8 years after commencing aspirin before a difference in CRC risk manifests in people taking aspirin compared with a population not taking aspirin.
Diagnosis and management of Lynch syndrome
Penelope Edwards1, http://orcid.org/0000-0002-7918-4003Kevin J Monahan2,3 1 Gastrointestinal and Lymphoma Units, Royal Marsden NHS Foundation Trust, London, UK 2 Lynch Syndrome Clinic, The Centre for Familial Intestinal Cancer, St Marks Hospital, London, UK 3 Faculty of Medicine, Department of Surgery & Cancer, Imperial College London, London, UK Correspondence to Dr Kevin J Monahan, Lynch Syndrome Clinic, The Centre for Familial Intestinal Cancer, St Mark's Hospital, London, HA1 3UJ, UK;...
Diagnosis and management of Lynch syndrome
Penelope Edwards1, http://orcid.org/0000-0002-7918-4003Kevin J Monahan2,3 1Gastrointestinal and Lymphoma Units, Royal Marsden NHS Foundation Trust, London, UK 2Lynch Syndrome Clinic, The Centre for Familial Intestinal Cancer, St Marks Hospital, London, UK 3Faculty of Medicine, Department of Surgery & Cancer, Imperial College London, London, UK Correspondence to Dr Kevin J Monahan, Lynch Syndrome Clinic, The Centre for Familial Intestinal Cancer, St Mark's Hospital, London, HA1 3UJ, UK;...
Michigan election chief: Trump suggested I be arrested for treason and executed
Jocelyn Benson, Michigan's top election official, faced an onslaught of threats after the 2020 presidential electionfor refusing to overturn results that showed Joe Biden had won the state.In those hectic weeks, she says she also received an especially disturbing piece of information: President Donald Trump suggested in a White House meeting that she should be arrested for treason and executed. Benson, a Democrat, revealed the alleged remark for the first time in an interview with NBC News.
Michigan election chief: Trump suggested I be arrested for treason and executed
May 19, 2022, 8:05 PM UTC By Cynthia McFadden, Kevin Monahan and Alexandra Chaidez Jocelyn Benson, Michigan’s top election official, faced an onslaught of threats after the 2020 presidential electionfor refusing to overturn results that showed Joe Biden had won the state.In those hectic weeks, she says she also received an especially disturbing piece of information: President Donald Trump suggested in a White House meeting that she should be arrested for treason and executed.
Sex-Specific Prevalence, Incidence, and Mortality Associated With Atrial Fibrillation in Heart Failure:
Abstract Objectives This study sought to investigate the mortality associated with atrial fibrillation (AF) in men and women with heart failure (HF) according to the sequence of presentation and rhythm versus rate control. Background The sex-specific epidemiology of AF in HF is sparse. Methods Using the Danish nationwide registries, all first-time cases of HF were identified and followed for all-cause mortality from 1998 to 2018.
Finding the needle in the haystack; the diagnostic accuracy of the faecal immunochemical test for colorectal cancer in younger symptomatic patients
ORIGINAL ARTICLE Nigel D’Souza, Croydon University Hospital University Hospital Southampton Imperial College London Search for more papers by this author Kevin Monahan, Imperial College London St Mark’s Hospital Search for more papers by this author Sally C.
A decades-long fight over an electric shock treatment led to an FDA ban. But the fight is far from over.
Rico Torres was just eight the first time school staffers strapped electrodes to his legs and shocked him. They draped a 12-volt battery over his shoulders in a backpack, while a nearby teacher held a clear plastic box with a photo of his face attached. When Torres misbehaved, the teacher would reach inside the box and push a button that sent a two-second jolt of electricity coursing through his body.
For food banks filling the gap left by SNAP, Biden changes to food program will be a welcome respite
DETROIT — Kinda Makini-Anderson has been providing hot meals to households on Detroit's east side throughout the Covid-19 pandemic. By her count, Makini-Anderson's nonprofit Inner City Youth Group has provided over 150,000 meals in the last 10 months. "We have always been there since 2009, assisting the community," she said, on a recent snowy morning after delivering breakfast to a local family.
Management strategies for the colonoscopic surveillance of people with Lynch syndrome during the COVID-19 pandemic
Management strategies for the colonoscopic surveillance of people with Lynch syndrome during the COVID-19 pandemic Free http://orcid.org/0000-0002-7918-4003Kevin J Monahan1,2, Anne Lincoln3, James E East4, Sally Benton5, John Burn6, Bianca DeSouza7, Helen Hanson8, Fiona Lalloo9, Terri McVeigh10, http://orcid.org/0000-0001-9507-0295Matthew D Rutter11,12, Katie Snape8, Huw J W Thomas1,2, Peter Sasieni3 1 The Lynch Syndrome and Family Cancer Clinic, St Mark's Hospital and Academic Institute,...
Hidden hunger: Elderly hunger is on the rise during Covid
Every weekday morning for nearly 20 years, Andrew Smith has woken up at dawn. He drives to a senior center in Brooklyn and loads up a refrigerated truck with warm meals as the sun rises over New York City. Smith is a delivery driver for Riseboro, a community partner with Citymeals on Wheels. His job is to deliver a warm meal — and a sense of security — to 92 homebound seniors every day.
Is the outcome of the election really in doubt? Original
More than a week after Election Day, incumbent President Donald Trump is still promising his supporters a win and Republican lawyers are still pursuing claims of election improprieties in half a dozen states. But is the result of the election really in doubt? Conversations with more than a dozen state election chiefs around the country and with election lawyers and experts indicate that recounts will likely not move states like Wisconsin and Georgia into Trump's column.
Chinese parts, hidden ownership, growing scrutiny: Inside America’s biggest voting machines maker
Chinese parts, hidden ownership, growing scrutiny: Inside America’s biggest voting machines maker. By Ben Popken, Cynthia McFadden and Kevin Monahan OMAHA, Neb. — Just off a bustling interstate near the border between Nebraska and Iowa, a 2,800-square-foot American flag flies over the squat office park that is home to Election Systems & Software LLC.
Here's how most states use signatures to verify voters' identities, or nullify their ballots
Fueled by concerns over the pandemic, as many as 80 million Americans are expected to cast their votes by mail in this year’s presidential election, more than double the number who did so in 2016. That surge has caused renewed interest in the way the majority of states verify the identities of mail-in voters — via their signatures.
A thrilling end to the softball season for ADSL teens
Kevin P. Monahan, Special to the Reporter The championship-winning Eagles (front, l-r): Jolise Grullon, Charlotte Doherty, Emme Finnegan, and Madelyn Murphy; (back, l-r) Coach Michael Hegarty, Carol Casado, Maeve Doherty, Ava Duffy, Kaitlyn Murphy, Keira Flynn, Monica Kelly, Emma Astrofsky, Coach Noreen Kelly, and Coach Matt Kelly. Photos by Kevin P.
Crusaders win ADSL girls softball championship
Crusader Team (Top row, l-r): Anna Mullen, Sarah Mullen, Christina George, Caitlin Sweeney, Kalin Walsh, Riley Porter, Emma Allen. Kelly McKenna. Grace Foley. Sarah Lynch Mallory Hanlon. Front row, from left: Ava Porter, Zoe Baxter, Maggie Januliwitz, Izzy McQuaide, Molly Hearon, Rory Shields. On Friday night, more than 100 spectators witnessed a gem of ADSL girls’ softball Majors championship game at Toohig Park.
Expert says U.S. has two weeks to get its act together to avoid a mess on Election Day Original
On June 23, Suraj Patel challenged incumbent congresswoman Carolyn Maloney in New York's Democratic primary. Six weeks after Election Day, Patel is still a candidate — because there are so many absentee ballots uncounted that officials have yet to declare a winner in his race. Election law expert Nate Persily says New York's problem could be the nation's problem come November without swift and drastic action.
'Online and vulnerable': Experts find nearly three dozen U.S. voting systems connected to internet
Added by Debra Tash on July 15, 2020. Saved under National-International, Politics Tags: Cynthia McFadden, Didi Martinez, internet, Kevin Monahan, NBC News, Online, Voting A team of election security experts used a “Google for servers” to challenge claims that voting machines do not connect to the internet and found some did.
Management strategies for the colonoscopic surveillance of people with Lynch syndrome during the COVID-19 pandemic
Management strategies for the colonoscopic surveillance of people with Lynch syndrome during the COVID-19 pandemic Free http://orcid.org/0000-0002-7918-4003Kevin J Monahan1,2, Anne Lincoln3, James E East4, Sally Benton5, John Burn6, Bianca DeSouza7, Helen Hanson8, Fiona Lalloo9, Terri McVeigh10, http://orcid.org/0000-0001-9507-0295Matthew D Rutter11,12, Katie Snape8, Huw J W Thomas1,2, Peter Sasieni3 1The Lynch Syndrome and Family Cancer Clinic, St Mark's Hospital and Academic Institute,...
'I hit the trifecta': She was battling cancer. Then came coronavirus and the complications.
Eliza Paris was 25 years old when she was diagnosed with stage four appendix cancer, requiring 12 rounds of chemotherapy and an 18-hour surgery to remove her ovaries, gallbladder, spleen, appendix and part of her colon. She relearned how to walk in the halls of New York's Memorial Sloan Kettering Cancer Center. When she finished treatment and left, she hoped the cancer was gone and she would never have to come back.
'I hit the trifecta': She was battling cancer. Then came coronavirus and the complications.
Eliza Paris was 25 years old when she was diagnosed with stage four appendix cancer, requiring 12 rounds of chemotherapy and an 18-hour surgery to remove her ovaries, gallbladder, spleen, appendix and part of her colon. She relearned how to walk in the halls of New York's Memorial Sloan Kettering Cancer Center. When she finished treatment and left, she hoped the cancer was gone and she would never have to come back.
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