Tsumugi Shoji on Muck Rack

Tsumugi Shoji

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Articles

A PI(3,5)P 2 /CHMP4B axis on lysosomes is essential for microautophagic degradation of STING

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By Tsumugi Shoji, Ayumi Shinojima, Takuma Kishimoto, Kanako Sato, Yasunori Uchida, Satoshi Kusumi, Daisuke Koga, Eiji Yamamoto, Yoshinori Hirano, Hirofumi Shibata, Kazushi Izawa, Takahiro Yasumi, Ryota Sato, Jun Nakayama, Shigeki Higashiyama, Junya Hasegawa, Hiroaki Kajiho, Takehiko Sasaki, Yoshihiko Kuchitsu, Tomohiko Taguchi, Nana Ikegami, Eisuke Yumoto, Ruri Shindo, Ryo Ogino
| Nature Verified
Abstract Stimulator of interferon genes (STING) is critical for the type I interferon responses to pathogen- or self-derived cytosolic DNA. STING signalling is terminated by ESCRT-driven lysosomal microautophagy. How STING is directly encapsulated by lysosomes has not yet been understood. Here we show that two lysosomal components, a phosphoinositide PI(3,5)P2 and CHMP4B (a subunit of ESCRT-III subcomplex) are essential for STING encapsulation by lysosomes.
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A PI(3,5)P2/ESCRT-III axis terminates STING signalling by facilitating TSG101-mediated lysosomal microautophagy

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By Tomohiko Taguchi, Tsumugi Shoji, Ayumi Shinojima, Satoshi Kusumi
| biorxiv.org
Abstract Stimulator of interferon genes (STING) is critical for the type I interferon response to pathogen- or self-derived cytosolic DNA. STING is degraded by the endosomal sorting complexes required for transport (ESCRT)-driven lysosomal microautophagy (LMA), the impairment of which leads to sustained inflammatory responses. It has been unknown how ESCRT targets STING directly to lysosomes.
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