Tucker Hansen

Original InvestigationArticles in PressOpen access Affiliations & Notes aDepartment of Radiology, Cincinnati Children’s Hospital, Cincinnati, OH, USA (S.E.H.) bDepartment of Radiology, University of Cincinnati, Cincinnati, OH, USA (S.E.H.) cDepartment of Radiology, Children’s Hospital of Atlanta, Atlanta, GA, USA (G.L.J.) dWashington University School of Medicine, St. Louis, MO, USA (T.H., A.E.E., A.G., E.A.M., C.C.C.) eDivision of Biostatistics and Epidemiology, Cincinnati Children’s...

Dear Editor: Acute myeloid leukemia (AML) originates in the bone marrow (BM), but in some patients, leukemic cells infiltrate peripheral tissues such as the skin (leukemia cutis) or other organs (myeloid sarcoma), a phenomenon known as extramedullary AML (eAML). eAML can present at initial diagnosis, during relapse after chemotherapy or allogeneic hematopoietic cell transplantation (allo-HCT), either in isolation or concurrently with BM involvement [1].

Abstract Extramedullary acute myeloid leukemia (eAML) is a rare form of myeloid neoplasm characterized by leukemic infiltration outside the bone marrow (BM). Despite its prognostic significance, eAML is often underdiagnosed and poorly characterized at molecular level. We performed a comprehensive genomic and immunogenomic profiling on paired BM and extramedullary specimens from 26 eAML patients, alongside over 400 AML cases without extramedullary involvement and 97 healthy controls.