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Tulio Silva Rosa

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Articles

Dual Immunohistochemistry Enhances Detection of Perineural Invasion in Oral Squamous Cell Carcinoma

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By Tulio Silva Rosa, Caroline Silva, Filipe Modolo, Nicole Lonni
| Wiley Online Library Verified
Perineural invasion (PNI) is a hallmark of tumor aggressiveness and a well-established predictor of poor prognosis in oral squamous cell carcinoma (OSCC). Accurate detection of PNI is critical for tumor staging, surgical decision-making, and post-treatment surveillance (Li et al. 2021; Quintana et al. 2022; Kurtz et al. 2005). However, PNI remains challenging to identify, and its underrecognition can compromise prognostic evaluation and therapeutic planning.
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