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Tuukka Norri

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Articles

Nanopore sequencing reveals hidden landscape of short L1 transductions in colorectal cancer - Communications Biology

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By Aurora Taira, Janne Ravantti, Tuukka Norri, Niko Välimäki, Anna Lepistö, Laura Renkonen-Sinisalo, Selja Koskensalo, Toni Seppälä, Ari Ristimäki, Anne K Mattila, Jan Böhm, Jukka-Pekka Mecklin, Annukka M. Pasanen, Oskari Heikinheimo, Ralf Bützow, Auli Karhu, Lauri A Aaltonen, Kimmo Palin, Tatiana Cajuso, Päivi Nummi, Kyösti Tahkola, Emma Siili
| Nature Verified
Abstract L1s are repetitive sequences capable of copying themselves into new genomic loci. While L1s are typically repressed by DNA methylation in somatic tissues, they can become reactivated in cancer. Although L1 sequences are highly repetitive, ~25% of insertions carry a unique downstream sequence, transduction, that can be used to trace the source L1.
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Linear time minimum segmentation enables scalable founder reconstruction

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By Veli Mäkinen, Tuukka Norri, Bastien Cazaux, Dmitry Kosolobov
| Biomed Central (BMC)
Algorithms for Molecular Biology201914:12 https://doi.org/10.1186/s13015-019-0147-6 ©  The Author(s) 2019 Received: 1 November 2018 Accepted: 4 May 2019 Published: 17 May 2019 Abstract Background We study a preprocessing routine relevant in pan-genomic analyses: consider a set of aligned haplotype sequences of complete human chromosomes.
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