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Articles by James Brown
Validation of a Novel, Low-Cost, Portable MRI-Compatible Exercise Device in Healthy Volunteers and Patients With Pulmonary Hypertension
1 Background Exercise cardiovascular magnetic resonance (CMR) is increasingly used to evaluate cardiovascular reserve. Several studies have shown that exercise CMR can be used to unmask underlying cardiac dysfunction, as well as to investigate the causes of exercise intolerance [1-4]. This is particularly true in pulmonary arterial hypertension (PAH) where exercise CMR has been used to assess contractile reserve [5, 6] and has been shown to be predictive of mortality [7].
Colorectal Cancer Complicated by Pulmonary Embolism and Potential Takotsubo Cardiomyopathy in a Person With Cystic Fibrosis: Diagnostic and Management Considerations
1 Introduction The treatment and life expectancy of people with cystic fibrosis (pwCF) has improved considerably since the discovery of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in the late 1980's [1]. Improved survival has seen unexpected complications arise, such as an increased risk of gastrointestinal malignancy [2]. In the case presented, we discuss management of an adult with colorectal cancer, in the setting of severe cystic fibrosis (CF) related lung disease.
How Clinical Skincare Is Evolving: The 70-Year Medical Legacy Behind Modern Barrier Repair
Lately, more dermatologists are talking about what happens with post-procedure skincare, not just the results. Whether it's laser, microneedling, or a simple resurfacing treatment, recovery has become part of the treatment plan. Patients are asking better questions. They want to know what helps the skin calm down, rebuild, and come back stronger. That's where clinical skincare has started to gain real traction.
Radiologic Evaluation of Subcutaneous Fat Necrosis Complicated by an Abscess in a Newborn: A Case Report
Specialty Please choose I'm not a medical professional. Allergy and Immunology Anatomy Anesthesiology Biostatistics Cardiac/Thoracic/Vascular Surgery Cardiology Critical Care Dentistry Dermatology Diabetes and Endocrinology Emergency Medicine Epidemiology and Public Health Family Medicine Forensic Medicine Gastroenterology General Practice Genetics Geriatrics Health Policy Hematology HIV/AIDS Hospital-based Medicine I'm not a medical professional.
Knee Stem Cell Injection Gains Attention as an Innovative
Autologous Bone Marrow Stem Cell Therapy (BMAC무릎줄기세포주사) for the knee has recently gained recognition as an innovative medical treatment, showing significant effectiveness in treating knee osteoarthritis. Eight studies on the BMAC (무릎줄기세포주사) injection, which was officially approved as a new medical technology in South Korea last year, have demonstrated its effectiveness in alleviating knee osteoarthritis pain.
Confidant Health Helps Healthcare Providers Sidestep Burnout (Here's How...)
Recent studies estimate that over 50% of healthcare providers experience burnout — a much higher percentage than the population at large. Areas that experience extremely high rates of demand, such as mental health practitioners, are especially vulnerable to burnout as they combine a full patient schedule with after-hours administrative tasks. When this happens, it becomes all too easy for basic self care and time for rest and recovery to fall by the wayside.
Send Your Parcel to Canada Fast & Securely Today
When it comes to sending parcels internationally, reliability and speed are key. Whether you're sending a gift, important documents, or an online order, you want your parcel to arrive safely and on time. If you're planning to send a parcel to Canada, it's essential to choose the right service that ensures quick delivery and security throughout the journey. Here’s a guide to help you get your parcel to Canada with ease. Why Send a Parcel to Canada?
Lateral Fitness Equipment Market : Industry Analysis Trends and Forecast By 2029
The Lateral Fitness Equipment Market sector is undergoing rapid transformation, with significant growth and innovations expected by 2029. In-depth market research offers a thorough analysis of market size, share, and emerging trends, providing essential insights into its expansion potential. The report explores market segmentation and definitions, emphasizing key components and growth drivers.
Fitness Equipment Market Growth Top Manufacturers, Future Investment, Revenue, Developments, Size, Share, and Forecast 2030
Fitness Equipment Market Poised for Steady Growth, Projected to Reach USD 17.16 Billion by 2032 Technological Advancements and Rising Health Consciousness Drive Market Expansion Market Overview The Fitness Equipment Market Growth is experiencing steady growth, with its valuation at USD 13.21 billion in 2024. Projections indicate an increase to USD 17.16 billion by 2032, reflecting a compound annual growth rate (CAGR) of 3.32% from 2025 to 2032.
Adaptive Example Selection: Prototype-Based Explainability for Interpretable Mitosis Detection
Abstract Understanding the decision-making process of black-box neural network classifiers is crucial for their adoption in medical applications, including histopathology and cancer diagnostics. An approach of increasing interest is to clarify how the decisions of neural networks compare to, and perform parallel to, those of highly-trained and knowledgeable clinicians and other medical professionals within their prototypical classes of interest.
Intraoperative neurophysiologic monitoring during cardiac surgery: an observational cohort study
Although existing data have demonstrated the effectiveness of dual-modality intraoperative neuromonitoring (IONM) in reducing adverse neurologic outcomes after aortic arch surgery and carotid endarterectomy, IONM during routine adult cardiac surgery has not yet been adopted as the clinical standard of care, despite suggestions by the American Heart Association.
Contact load practices and perceptions in elite English rugby league: an evaluation to inform contact load guidelines
Abstract Background: Athlete exposure to contact could be a risk factor for injury. Governing bodies should provide guidelines preventing overexposure to contact. Objectives: Describe the current contact load practices and perceptions of contact load requirements within men’s and women’s rugby league to allow the Rugby Football League (RFL) to develop contact load guidelines.
Validation of a novel, low-cost, portable MRI-compatible exercise device in healthy volunteers and patients with pulmonary hypertension
Funding Dr D.S.K. is supported by a British Heart Foundation (BHF) Clinical Research Leave Fellowship (FS/CRLF/20/23004) and by the National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre (BRC). Prof. M.F. is supported by a BHF Intermediate Fellowship (FS/18/21/33447). Declaration of interest There are no conflicts of interest in relation to the work in this manuscript.
Sanctioned illegal high tackles significantly increase concussion risk to both tacklers and ball carriers in elite men’s Rugby Union
Sanctioned illegal high tackles significantly increase concussion risk to both tacklers and ball carriers in elite men’s Rugby Union Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
UK Medical Cannabis: An Introductory Guide
In the domain of alternative medicine, UK medical cannabis emerges as a significant contender, offering a nuanced approach to holistic healing. This guide serves as a comprehensive exploration, shedding light on various facets of this alternative therapy. We delve into the legal landscape surrounding UK medical cannabis, elucidating the complexities governing its cultivation, distribution, and accessibility.
7 Effective Ways to Promote Online Safety and Digital Wellbeing in Schools
Technology and social media have become part of the fabric of daily life. Whilst they provide fantastic opportunities for education, creativity and connection, it is a challenge for young people to avoid over-engaging with them and their overuse can pose risks to wellbeing if not managed properly. This is particularly true for younger users who are still developing critical thinking skills and independence.
Risk factors associated with development of colitis in horses post‐exploratory laparotomy
1 INTRODUCTION Short-term complications associated with exploratory laparotomy in the horse include colic, incisional complications, postoperative ileus, endotoxaemia, thrombophlebitis, septic peritonitis, diarrhoea and colitis.1 Colitis may result from non-infectious (e.g., inflammatory bowel disease, sand enteropathy) and infectious (e.g., Salmonellosis) etiologies. Diagnosis of infectious colitis has been shown to impact morbidity and mortality in hospitalised horses.
Quest for clarity: investigating concussion-related responsibilities across the New Zealand Rugby Community System
The framework of concussion responsibilities across stakeholders that form part of the NZR community system is presented in table 3. Level 1: responsibilities of the governing body (NZR) The nature of the responsibilities identified was conceptually broader in scope compared with the lower levels of the community rugby system.
How to harness and improve on video analysis for youth rugby player safety: a narrative review
Video coding and labelling One of the main limitations when identifying injury and concussion risk factors and mechanisms through video analysis across youth and professional video is the inability to find the injury-inducing event in the captured footage (table 1).
Students in the Forest: The Role of Design‐Build Pedagogies in Repairing Material Disconnections in Architecture Education
Abstract This article explores an intellectual disconnection in architectural education about the conception of wood as a building material. It explores initiatives to develop in future architects a deeper consciousness of the complex ecology of timber, promoting its sustainable use in the building industry.
Association of Biomarker-Based Artificial Intelligence With Risk of Racial Bias in Retinal Images
Association of Biomarker-Based Artificial Intelligence With Risk of Racial Bias in Retinal Images Key Points Question Does converting a fundus photograph to a retinal vessel map (RVM) remove information relevant to self-reported race (SRR) in artificial intelligence (AI) training?
Bring balance back to the Montana Supreme Court
I'm a fourth-generation Montanan who grew up in Dillon, small business owner, private practice attorney and public servant. My entire 15-plus year legal career has been dedicated to protecting the legal rights of Montanans and upholding the rule of law. I have primarily represented Montana's farmers, ranchers, and small business owners in both state and federal courts.
Supporting health equity in dermatology starts with acknowledging no one’s skin is exactly the same - PharmaVOICE
By: Mike Gladstone, Global President of Inflammation & Immunology at Pfizer I’ll never look at skin the same way again. A year ago, when I transitioned into my leadership role with Pfizer Inflammation & Immunology, I was excited to learn about the fascinating depth and complexity of autoimmune medicine, especially in dermatology. But some of the most important things I have learned are about more than science and biology. They are about vision, perception, empathy, acceptance and equity.
02.16.21 -- Inside BioCardia's Investigational CardiAMP Cell Therapy For Heart Failure
Newsletter | February 16, 2021 Greetings Cell & Gene readers, Just recently, I caught up with Peter Altman, Ph.D., CEO at BioCardia, to learn more about the company’s CardiAMP Heart Failure Trial and its best possible outcomes for patients. Here’s what Altman had to say. Dendritic cell (DC)-based therapies have emerged as an exciting avenue of cell-based therapy.
BokSmart rugby safety education courses are associated with improvements in behavioural determinants in attending coaches and referees: presurvey-postsurvey study | Injury Prevention
BokSmart rugby safety education courses are associated with improvements in behavioural determinants in attending coaches and referees: presurvey–postsurvey study http://orcid.org/0000-0002-7778-7783James Craig Brown1,2,3, http://orcid.org/0000-0002-3416-6266Sharief Hendricks2,4, http://orcid.org/0000-0001-8979-1504Michael Ian Lambert2, Willem van Mechelen2,5, Evert Verhagen2,5 1Institute of Sport and Exercise Medicine, Division of Orthopaedic Surgery, Department of Surgical Sciences, Faculty...
Epigenetic Regulation To Treat Acute Organ Injury And Chronic Liver Diseases
Alcoholic hepatitis (AH) is a life-threatening acute liver disease caused by chronic alcohol abuse with no approved drugs and a 28-day overall mortality rate of 26%. About 120,000 patients are hospitalized with AH diagnoses every year in the United States. In addition, about one-third of the U.S. population suffers from fatty liver disease. Ten percent of these cases have chronic cirrhosis-based fibrosis and chronic inflammation of the liver due to excess storage of fat in the liver.
Airbus A220 CSeries CS100 FTV1 Face Mask for Sale by Sylvain Faust
Boundary: Bleed area may not be visible. Click and drag to re-position the image, if desired. $13.95 Image Size Warning The image is near the edges of the product but doesn't cover the entire product. Some of the background color may appear around the outside edges of the image.
Siamese neural networks for continuous disease severity evaluation and change detection in medical imaging
Abstract Using medical images to evaluate disease severity and change over time is a routine and important task in clinical decision making. Grading systems are often used, but are unreliable as domain experts disagree on disease severity category thresholds. These discrete categories also do not reflect the underlying continuous spectrum of disease severity.
Q: What breakthrough technologies have had a transformative effect on your business in 2019?
Breakthrough Technologies Thom O’Sullivan, Director of Aseptic Process Technology, Process GS&T, IPS-Integrated Project Services, LLC A: Many of the change agents I have seen in 2019 are derived from changes in regulatory law, commercial downscaling, and impact from patent expiry strategies. The largest external regulatory change came from the issuance of the long-awaited EMEA Annex I, clarifying which technologies are required and acceptable, when and why.
Q: What developing technologies do you believe will have the greatest impact on the biopharma industry in 2020 and beyond?
BioPharma 2020 James E. Brown, D.V.M., President and Chief Executive Officer, DURECT Corporation A: During the last decade, the biopharma industry has made significant advancements in the discovery and development of new therapeutics; however, there are still many patients suffering from diseases, and they are still looking for effective treatment options.
QYResearch: Aerospace Wiring Harness Industry Market Overview by 2019-2025
This research study is one of the most detailed and accurate ones that solely focus on the global Aerospace Wiring Harness market. It sheds light on critical factors that impact the growth of the global Aerospace Wiring Harness market on several fronts. Market participants can use the report to gain sound understanding of the competitive landscape and strategies adopted by leading players of the global Aerospace Wiring Harness market.
Ending the doctor-nurse game by enhancing the role of the ward nurse
James S Brown, oral and maxillofacial surgeon and honorary professor Liverpool University, Aintree University Hospital, Liverpool L9 7AL, UK brownjs{at}doctors.org.uk A longstanding error in medicine is putting the most inexperienced member of the doctor team in the most vulnerable and important situations, when patients need expert decisions and management.1 At present, the junior trainee sleeping at the hospital …
Inaccurate diagnosis of COPD: the Welsh National COPD Audit
Research Marie Fisk, Viktoria McMillan, James Brown, Juliana Holzhauer-Barrie, Muhammad S Khan, Noel Baxter and C Michael Roberts British Journal of General Practice 2019; 69 (678): e1-e7. DOI: https://doi.org/10.3399/bjgp18X700385 Abstract Background The diagnosis of chronic obstructive pulmonary disease (COPD) is confirmed with spirometry demonstrating persistent airflow obstruction.
High-Pressure Speed of Sound Measurements of trans-1-Chloro-3,3,3-trifluoropropene (R1233zd(E)) in Liquid Region for Temperature from (273.15 to 353.15) K
This paper presents speed of sound measurements of liquid trans-1-chloro-3,3,3-trifluoropropene (R1233zd(E)) along six isotherms over the temperature range from (273.15 to 353.15) K for pressures up to 35 MPa by means of the double pulse–echo method. The expanded uncertainty of the speed of sound measurements at a confidence level of 95% is 0.1%.
A case of platypnoea orthodeoxia following Laproscopic Cholecystectomy
Contributors All listed authors have met the criteria for authorship set out in the ICMJE guidelines. All authors contributed to the thought, discussion, design and editing of the report. The majority of the writing of the article was done by the lead author with contributions from co-authors.
Government of Canada investing in safety at local airports
Canadians, tourists and businesses benefit from safe and well-maintained airports. From visiting friends and family, to traveling to medical appointments, or getting goods to market, people rely on local airports to support and sustain vibrant communities. These airports also provide essential air services including community resupply, air ambulance, search and rescue and forest fire response.
Lexington must be open to a police chief from outside the department | Lexington Herald Leader
Let me start by thanking retiring Police Chief Mark Barnard for his leadership and 31 years of service with the Lexington Police Department. And thanks to Assistant Chief Ron Compton for his willingness to serve as acting chief. Our city is better because of the leadership and dedication of our past chiefs.
Utilizing a transfer of care bundle to reduce unplanned readmissions to the cardiac intensive care unit
Through observation of our own internal CICU to cardiac step-down unit processes, we identified that standard transfer of care and monitoring practices were not differentiated based on patient-specific risk. We hypothesised that undifferentiated monitoring of all patients regardless of risk allowed subtle clinical changes to go unrecognised until the needs became more urgent, resulting in more invasive and complex interventions such as readmission to the CICU.
iterative Random Forests to discover predictive and stable high order interactions
AbstractGenomics has revolutionized biology, enabling the interrogation of whole transcriptomes, genome- wide binding sites for proteins, and many other molecular processes. However, individual genomic assays measure elements that interact in vivo as components of larger molecular machines. Understanding how these high-order interactions drive gene expression presents a substantial statistical challenge.
Discover CKUA Treasures from the Vault - CKUA Radio Network
CKUA Radio Orchestra at the University of Alberta, 1928-29. Mrs. J.B. Carmichael is standing tall toward the back, near to microphone, wearing long necklace. Our delve into the vast archival collection and colourful characters that make up CKUA continues with the latest Treasures from the Vault feature brought to you by the Edmonton Heritage Council.
Measuring a Healthy Return on Your Benefits Communication - HR Daily Advisor
Employees may be one of the largest expenses for a company, but talent is also a company’s greatest asset. And in today’s increasingly competitive marketplace, more and more companies are looking to benefits packages to maintain their competitive advantage to attract and retain top employees.
Utilizing a transfer of care bundle to reduce unplanned readmissions to the cardiac intensive care unit
Through observation of our own internal CICU to cardiac step-down unit processes, we identified that standard transfer of care and monitoring practices were not differentiated based on patient-specific risk. We hypothesised that undifferentiated monitoring of all patients regardless of risk allowed subtle clinical changes to go unrecognised until the needs became more urgent, resulting in more invasive and complex interventions such as readmission to the CICU.
An unusual cause for diffuse pulmonary nodules
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BSRA 2017 at the University of Exeter - BSRA
How –omics technologies allow detailed dissection of ageing processes and age-related disease. Public lecture by Prof Judith Campisi, The Buck Institute for Aging Research, USA Conference dinner at Reed Hall, a stunning grade II listed building nestled in 300 acres of enchanting landscaped gardens. Registered participants of the BSRA 2017 ASM are eligible for a special daily registration rate at the 13th World Congress on Inflammation, July 8 – 12th 2017.
Guest opinion: U.S. mega-banks too big to manage
HELENA — The recent fine of $185 million handed down to Wells Fargo, following an investigation by the Consumer Financial Protection Bureau and the Office of the Comptroller of the Currency, highlights the importance of choosing your banking partner carefully.The investigation found that, according to the consent order Wells Fargo signed, approximately 5,300 employees of Wells Fargo were involved in a scheme resulting in more than 2 million fake accounts that “may not have been authorized”...
Using an expanding nondirect product harmonic basis with an iterative eigensolver to compute vibrational energy levels with as many as seven atoms
We demonstrate that it is possible to use a variational method to compute 50 vibrational levels of ethylene oxide (a seven-atom molecule) with convergence errors less than 0.01 cm?1. This is done by beginning with a small basis and expanding it to include product basis functions that are deemed to be important. For ethylene oxide a basis with fewer than 3 × 106 functions is large enough.
Association between exercise-induced pulmonary hemorrhage and performance in Thoroughbred racehorses
Abstract Objective—To determine whether exercise-induced pulmonary hemorrhage (EIPH) was associated with racing performance in Thoroughbred horses not medicated with furosemide and not using nasal dilator strips. Design—Observational cross-sectional study. Animals—744 two- to 10-year-old Thoroughbred horses racing in Melbourne, Australia. Procedure—Horses were enrolled prior to racing, and a tracheobronchoscopic examination was performed after 1 race.
The CPA as Fraud-Buster
EXECUTIVE SUMMARY SAS NO. 82 PROVIDES guidance about auditors' responsibilities in detecting and reporting possible fraud. Practitioners need to examine the presence of risk factors, assess the risk of material misstatement due to fraud, develop a response, document the performance of their assessment and meet their communication responsibilities. MANAGEMENT HAS TO CREATE a proper control environment and establish control activities.
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