Udesh Dhawan

1 Introduction Cells sense mechanical signals from the surrounding environment, the extracellular matrix (ECM), and transduce them into biochemical signals through mechanotransductive processes[1, 2] While attaching to their underlying matrix, cells probe it to sense its stiffness, viscosity, and topography.[3-6] Cells then bind to the ECM via integrins, specifically to ECM proteins through so-called focal adhesions (FA).[7, 8] The molecular clutch model[9-11] explains how cells mechanically...

Manuel Salmeron-Sanchez Centre for the Cellular Microenvironment, Mazumdar-Shaw Advanced Research Centre, University of Glasgow, Glasgow, G116EW UK Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, 08028 Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, 08010 Spain Search for more papers by this author

Hydrogen-Treated CoCrMo Alloy: A Novel Approach to Enhance Biocompatibility and Mitigate Inflammation in Orthopedic Implants The surface modification of cobalt-chromium-molybdenum (CoCrMo) alloy to create hydrogenated CoCrMo (H-CoCrMo) surfaces has shown promise as an anti-inflammatory orthopedic implant.