UGC Medicina Interna

AC alternating current ALP alkaline phosphatase DAC digital to analogue converter ECM extracellular matrix ES electrical stimulation MSC mesenchymal stem cells OCN osteocalcin OPG osteoprotegerina OSX transcription factor RANKL ligand for the RANK receptor RUNX2 RUNX transcription factor family 1 Introduction Bone regeneration therapy is essential for accelerating fracture repair, enhancing implant integration, and treating diseases that impair bone formation.

Many patients previously using darunavir/ritonavir (DRV/r) (800/100mg) have switched to darunavir/cobicistat (DRV/C) (800/150 mg) either as part of triple therapy (ART) or as monotherapy with DRV (mDRV). The latter approach continues to be used in some countries for patients receiving long-term treatment. However, to date, the behaviour of DRV/C in the seminal compartment has not been analysed.