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Articles by Ulla Sovio
Isthmin-2 is a first-trimester predictor of preeclampsia and fetal growth restriction
Abstract Preeclampsia and fetal growth restriction (FGR) are major causes of global morbidity and mortality. Both conditions are associated with impaired invasion of the uterus by extravillous trophoblast (EVT). We performed proteomics in maternal serum obtained at ~12 weeks of gestational age in a prospective pregnancy cohort (Pregnancy Outcome Prediction Study).
Mendelian Randomization With Longitudinal Exposure Data: Simulation Study and Real Data Application
1 Introduction Mendelian randomization (MR) allows to estimate the causal effect of an exposure X $$ X $$ on an outcome Y $$ Y $$ using genetic variants (single nucleotide polymorphisms [SNPs]) as instrumental variables (IVs), as long as certain assumptions are met [1]. The SNPs must be strong predictors of X $$ X $$ , while being independent of observed and unobserved confounders U $$ U $$ of X $$ X $$ and Y $$ Y $$ .
Raised Leptin and Pappalysin2 cell-free RNAs are the hallmarks of pregnancies complicated by preeclampsia with fetal growth restriction - Nature Communications
Abstract Preeclampsia (PE) and fetal growth restriction (FGR) complicate 5-10% of pregnancies and are major causes of maternal and fetal morbidity and mortality. Here we demonstrate that measuring circulating cell-free RNAs (cfRNAs) from maternal plasma can accurately predict pregnancies complicated by the combination of PE and FGR. We investigated 751 maternal plasma samples from 195 pregnant women (39 cases; 156 non-cases).
Mendelian Randomization with longitudinal exposure data: simulation study and real data application
JKB has received research funding for unrelated work from F. Hoffmann-La Roche Ltd. JP was supported by grants from the Wellcome Trust (225790/Z/22/Z) and the United Kingdom Research and Innovation Medical Research Council (MC_UU_00002/7) to SB. MP was supported by the MRC grant 'Looking beyond the mean: what within-person variability can tell us about dementia, cardiovascular disease and cystic fibrosis' (MR/V020595/1).
Placental Streptococcus agalactiae DNA is associated with neonatal unit admission and foetal pro-inflammatory cytokines in term infants - Nature Microbiology
Abstract Streptococcus agalactiae (Group B Streptococcus; GBS) is a common cause of sepsis in neonates. Previous work detected GBS DNA in the placenta in ~5% of women before the onset of labour, but the clinical significance of this finding is unknown. Here we re-analysed this dataset as a case control study of neonatal unit (NNU) admission.
Association between adverse pregnancy outcome and placental biomarkers in the first trimester: A prospective cohort study
1 INTRODUCTION Early pregnancy identification of women at increased risk of pregnancy complications has been a standard element of prenatal care for decades and women with high risk features in their medical or obstetric history are directed towards more intensive patterns of care.
Association between antenatal diagnosis of late fetal growth restriction and educational outcomes in mid-childhood: A UK prospective cohort study with long-term data linkage study
Statistical analyses The study analyses followed a prespecified statistical analysis plan agreed by all study authors (S1 Appendix). Children with relevant childhood morbidities (S1 Table) were included in the analyses, and the models were instead adjusted for this factor, rather than excluding this small number of children as their exclusion did not materially alter the results. Other primary analyses were conducted as planned.
Inherent mosaicism and extensive mutation of human placentas
Abstract Placentas can exhibit chromosomal aberrations that are absent from the fetus1. The basis of this genetic segregation, which is known as confined placental mosaicism, remains unknown. Here we investigated the phylogeny of human placental cells as reconstructed from somatic mutations, using whole-genome sequencing of 86 bulk placental samples (with a median weight of 28 mg) and of 106 microdissections of placental tissue.
Universal third-trimester ultrasonic screening using fetal macrosomia in the prediction of adverse perinatal outcome: A systematic review and meta-analysis of diagnostic test accuracy
Loading metrics Open Access Peer-reviewed Research Article Alexandros A. Moraitis, Norman Shreeve, Ulla Sovio, Peter Brocklehurst, Alexander E. P. Heazell, Jim G. Thornton, Stephen C. Robson, Aris Papageorghiou, Gordon C. Smith Alexandros A. Moraitis, Norman Shreeve, Ulla Sovio, Peter Brocklehurst, Alexander E. P. Heazell, Jim G. Thornton, Stephen C. Robson, Aris Papageorghiou, Gordon C.
Fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia
Abstract Pre-eclampsia (typically characterized by new-onset hypertension and proteinuria in the second half of pregnancy) represents a major determinant of the global burden of disease1,2. Its pathophysiology involves placental dysfunction, but the mechanism is unclear. Viral infection can cause organ dysfunction, but its role in placentally related disorders of human pregnancy is unknown3.
A maternal serum metabolite ratio predicts fetal growth restriction at term
Abstract Fetal growth restriction (FGR) is the major single cause of stillbirth1 and is also associated with neonatal morbidity and mortality2,3, impaired health and educational achievement in childhood4,5 and with a range of diseases in later life6. Effective screening and intervention for FGR is an unmet clinical need.
Author Correction: Human placenta has no microbiome but can contain potential pathogens
Access provided by Correction to: Nature https://doi.org/10.1038/s41586-019-1451-5, published online 31 July 2019. In this Article, the Supplementary Information file containing the 16S rRNA sequencing results has been adapted to include a second tab labelled ‘ENA link’ that provides direct links between individual raw data files in the European Nucleotide Archive (ENA) and the sample numbers used in the Article.
GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
Abstract Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood.
Authors’ reply re: Evaluation of a simple risk score to predict preterm pre‐eclampsia using maternal characteristics: a prospective cohort study
BJOG Exchange Authors’ reply re: Evaluation of a simple risk score to predict preterm pre‐eclampsia using maternal characteristics: a prospective cohort study PDF PDF Share Sir, I thank Roaa Al‐bedaery and Pippa Oakeshott1 for their interest in our paper which demonstrated a clinically useful prediction of the risk of preterm pre‐eclampsia by a simple risk score derived from the model used in the ASPRE trial.
Human placenta has no microbiome but can contain potential pathogens
Abstract We sought to determine whether pre-eclampsia, spontaneous preterm birth or the delivery of infants who are small for gestational age were associated with the presence of bacterial DNA in the human placenta. Here we show that there was no evidence for the presence of bacteria in the large majority of placental samples, from both complicated and uncomplicated pregnancies.
Screening for breech presentation using universal late-pregnancy ultrasonography: A prospective cohort study and cost effectiveness analysis
Loading metrics Open Access Peer-reviewed Research Article David Wastlund , Alexandros A. Moraitis, Alison Dacey, Ulla Sovio, Edward C. F. Wilson, Gordon C. S. Smith David Wastlund, Alexandros A. Moraitis, Alison Dacey, Ulla Sovio, Edward C. F. Wilson, Gordon C. S.
Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity
Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity N. Maneka G. De Silva, Sylvain Sebert, Alexessander Couto Alves, Ulla Sovio, Shikta Das, Rob Taal, Nicole M. Warrington, Alexandra M. Lewin, Marika Kaakinen, Diana Cousminer, Elisabeth Thiering, Nicholas J. Timpson, Ville Karhunen, Tom Bond, Xavier Estivill, Virpi Lindi, Jonathan P. Bradfield, Frank Geller, Lachlan J. M. Coin, Marie Loh, Sheila J. Barton, Lawrence J.
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