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Articles

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes

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By Yuanzhao Cao, Meredith A. Redd, Jennifer E. Outhwaite, Dalia Mizikovsky, Chen FANG, Courtney Vedelago, Clarissa Tan, Zhixuan Wu, Robin W. Palfreyman, Ulrich Thomas, Julian Sng, Natalie J. Saez, Helen Barrett, Emily S. Dorey, Glenn King, Alain Wuethrich, Matt Trau, Sonia Shah, Kirsty Short, Nathan J Palpant, Dara Daygon, Terra Stark, Elena Dragicevic
| Nature Verified
Abstract Heart disease is the leading cause of morbidity and mortality in individuals with diabetes, due largely to risks associated with ischaemic injuries such as myocardial infarction (MI). We use human population genetic data to demonstrate that classical cardiovascular disease risk biomarkers, including common measures of hyperglycaemia, do not fully account for the increased risk of post-MI mortality in patients with diabetes.
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