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Uma Vrudhula on Muck Rack

Uma Vrudhula

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Disruption of Cholinergic Retinal Waves Alters Visual Cortex Development and Function

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By Jacob M. Ratliff, Deepanjali Dwivedi, Timothy J Burbridge, Uma Vrudhula
| BioRxiv
Abstract Retinal waves represent an early form of patterned spontaneous neural activity in the visual system. These waves originate in the retina before eye-opening and propagate throughout the visual system, influencing the assembly and maturation of subcortical visual brain regions. However, because it is technically challenging to ablate retina-derived cortical waves without inducing compensatory activity, the role these waves play in the development of the visual cortex remains unclear.
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