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Ung Seop Jeon on Muck Rack

Ung Seop Jeon

As seen in: PLOS Biology, BioRxiv
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Articles

Wnt target gene activation requires β-catenin separation into biomolecular condensates

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By Richard Stewart, Zhihao Ding, Ung Seop Jeon
| PLOS Biology Verified
Materials and methods FLAG-tagged β-catenin variants were expressed in transient transfection assays using the pCDNA3.1 vector (Thermo Fisher Scientific). A plasmid expressing human β-catenin containing a S33Y mutation (pCDNA3-S33Y) was the starting point for further mutagenesis [88]. β-catenin mutants were created using gBLOCKS (Integrated DNA Technologies) which were subcloned into pCDNA3-S33Y that was linearized with either BamHI & PmlI (N-IDR mutants) or BbvCI & XbaI (C-IDR mutants).
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Isoform-specific aPKC renders primary cilia dispensable for Hedgehog signaling and basal cell carcinoma growth

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By Tuyen Nguyen, Kirsten Wong, Vama Jhumkhawala, Ung Seop Jeon
| BioRxiv
Abstract Primary cilia loss is a common feature of advanced cancers. While primary cilia are necessary to initiate Hedgehog (HH)-driven cancers, how HH pathway activity is maintained in advanced cancers devoid of primary cilia is unclear. Here, we find that HH-driven basal cell carcinoma (BCC) accumulates mutations in Alstrom and Usher syndrome genes.
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