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Universitaire Grenoble Alpes

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Intracranial pressure monitoring with and without brain tissue oxygen pressure monitoring for severe traumatic brain injury in France (OXY-TC): an open-label, randomised controlled superiority trial

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By Jean-François Payen, Grenoble Institut Neurosciences, Yoann Launey, Universitaire Grenoble Alpes
| The Lancet Verified
Background Optimisation of brain oxygenation might improve neurological outcome after traumatic brain injury. The OXY-TC trial explored the superiority of a strategy combining intracranial pressure and brain tissue oxygen pressure (PbtO2) monitoring over a strategy of intracranial pressure monitoring only to reduce the proportion of patients with poor neurological outcome at 6 months. Methods We did an open-label, randomised controlled superiority trial at 25 French tertiary referral centres.
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