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Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects - Nature Communications

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By Ritobrata Ghose, Fabio Pezzano, Savvas Kourtis, Antoni Ganez Zapater, Lorena Espinar, Antonio Zorzano, Verena Ruprecht, Upamanyu Ghose
| Nature Verified
Abstract The physical tissue microenvironment regulates cell state and behaviour. How mechanical confinement rewires the subcellular localisation of organelles and affects cellular metabolism is largely unknown. In this study, proteomics analysis revealed that cellular confinement induced a strong enrichment of mitochondrial proteins in the nuclear fraction.
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