UPR “Chronotherapy

We have read with great interest the recent comprehensive systematic review on chronomodulated chemotherapy by Markella Printezi and colleagues.An updated critical revision of available evidence was overdue, given that the previous one was published nearly 30 years ago.Although only a small number of randomised controlled clinical trials involving chronomodulated or circadian-based chemotherapy have been done in the interval between these two systematic reviews, two major developments need to...

The delivery of treatments according to circadian rhythms, known as chronotherapy, has been instrumental in the discovery of oxaliplatin efficacy and safety in colon cancer and the efficacy of neoadjuvant chemotherapy for liver metastases from colorectal cancer in the late 1990s. 2 Giacchetti S Itzhaki M Gruia G et al. Long-term survival of patients with unresectable colorectal liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. Ann Oncol.