Upregulating EGFR Expression

1 Introduction Glioblastoma multiforme (GBM), the most aggressive primary brain tumor, remains a formidable clinical challenge due to its highly infiltrative nature, intratumoral and intertumoral heterogeneity, and resistance to conventional therapies [1, 2]. The complex tumor microenvironment (TME) plays a crucial role in GBM progression, drug response and recurrence. Indeed, the cross-talk between the tumor and the surrounding tissue helps cells to survive and escape treatments [3].