Utako Yokoyama

Abstract Aims: Cyclooxygenase2 and microsomal prostaglandin E synthase1derived prostaglandin E2 (PGE2) are involved in vascular intimal hyperplasia (IH). Although extensive studies have revealed the roles of PGE2 receptors (EPs) in IH, spatiotemporal EP expressions and downstream targets have not been fully elucidated. In this study, we focused on EP4 and investigated its role in vascular IH.

MAIN TEXT Utako Yokoyama Corresponding Author uyokoyam@tokyo-med.ac.jp orcid.org/0000-0003-1803-0155 Department of Physiology, Tokyo Medical University, Shinjuku‐ku, Tokyo, Japan Cardiovascular Research Institute, Yokohama City University, Yokohama, Kanagawa, Japan Corresponding Author: Utako Yokoyama, Department of Physiology, Tokyo Medical University, 6‐1‐1 Shinjuku, Shinjuku‐ku, Tokyo 160‐8402, Japan E‐mail: uyokoyam@tokyo-med.ac.jp Yoshihiro Ishikawa, Cardiovascular Research Institute,...

Abstract In adipocytes, intracellular Ca2+ and Mg2+ modulates physiological functions, such as insulin action and the secretion of adipokines. TRPM7 is a Ca2+/Mg2+‐permeable non‐selective cation channel. TRPM7 mRNA is highly expressed in adipose tissue, however, its functional expression in adipocytes remains to be elucidated.