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V. Krishnan Ramanujan on Muck Rack

V. Krishnan Ramanujan

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Articles

Hexokinase dissociation from mitochondria promotes oligomerization of VDAC that facilitates NLRP3 inflammasome assembly and activation

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By Aaron Silva-Sanchez, Sung Hoon Baik, Manasa Mellacheruvu, V. Krishnan Ramanujan
| Science Magazine Verified
Editor’s summary Various danger signal–initiated proinflammatory signaling pathways converge on activation of the NLRP3 inflammasome complex. Mitochondria are key intermediaries in NLRP3 activation, but specifying the roles of individual mitochondrial components in this pathway has been an elusive goal. Baik et al.
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