VA Pittsburgh HS

This study comprised 176 plasma samples from 113 participants (average age 76.7 years at baseline, 54.0% women, and 95.0% non-Hispanic White) from the MYHAT-NI cohort (see Table 1 for demographic characteristics). These participants were recruited from the parent MYHAT cohort, which includes areas with relatively low socioeconomic status. The median Area Deprivation Index (ADI) in the MYHAT study area is at the 85th percentile nationally, according to the Neighborhood Atlas [54].

Abstract Blood-based biomarkers are gaining grounds for the detection of Alzheimer’s disease (AD) and related disorders (ADRDs). However, two key obstacles remain: the lack of methods for multi-analyte assessments and the need for biomarkers for related pathophysiological processes like neuroinflammation, vascular, and synaptic dysfunction. A novel proteomic method for pre-selected analytes, based on proximity extension technology, was recently introduced.

The quality of laboratory and clinical assays has greatly improved due to advances in instrument technology, particularly the use of automated equipment, which has led to higher reproducibility through standardized procedures. However, analytical errors/variations from various sources may still occur and render results unusable or confound study findings.