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Vadde Ramu on Muck Rack

Vadde Ramu

Germany, Paris
As seen in: Wiley Online Library, ACS Publications, Royal Society of Chemistry
Marie Sklodowska-Curie Fellow
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Articles

Cell viability imaging in tumor spheroids via DNA binding of a ruthenium(II) light-switch complex

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By Vadde Ramu, Lukas Wijaya, Nataliia Beztsinna, Sylvestre Bonnet
| Royal Society of Chemistry Verified
Cell viability imaging in tumor spheroids via DNA binding of a ruthenium(ii) light-switch complex† The famous ‘‘light-switch’’ ruthenium complex [Ru(bpy)2(dppz)](PF6)2 (1) has been long known for its DNA binding properties in vitro. However, the biological utility of this compound has been hampered by its poor cellular uptake in living cells.
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Red‐Light Activation of a Microtubule Polymerization Inhibitor via Amide Functionalization of the Ruthenium Photocage

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By Ludovic Bretin, Yurii Husiev, Vadde Ramu, Liyan Zhang
| Wiley Online Library Verified
Introduction Microtubules are dynamic, ATP-dependent supramolecular polymers of tubulin.
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The Self-Assembly of a Cyclometalated Palladium Photosensitizer into Protein-Stabilized Nanorods Triggers Drug Uptake In Vitro and In Vivo

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By Xue-Quan Zhou, Ming Xiao, Vadde Ramu, Jonathan Hilgendorf
| ACS Publications
Introduction Research on metal-based anticancer drugs has been encouraged for many years by the clinical success of cisplatin, carboplatin, oxaliplatin, and nedaplatin, four metal-based drugs used in the treatment of cancer.(1−3) However, the similar mode of action of these platinum-based compounds, where aquation of some of the leaving groups by intracellular water leads to nonselective covalent binding of platinum to DNA, results in significant side effects and drug resistance.(3−10)...
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