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Vaha Akbary Moghaddam on Muck Rack

Vaha Akbary Moghaddam

As seen in: Science Magazine, BioRxiv, medRxiv
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Articles

FISHNET: A Network-based Tool for Analyzing Gene-level P-values to Identify Significant Genes Missed by Standard Methods

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By Sandeep Acharya, Vaha Akbary Moghaddam, Woo Seok Jung, Yu Kang
| BioRxiv
Abstract FISHNET uses prior biological knowledge, represented as gene interaction networks and gene function annotations, to identify genes that do not meet the genome-wide significance threshold but replicate nonetheless. Its input is gene-level P-values from any source, including omicsWAS, aggregation of GWAS P-values, CRISPR screens, or differential expression analysis.
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Construction of Multi-Modal Transcriptome-Small Molecule Interaction Networks from High-Throughput Measurements to Study Human Complex Traits

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By Vaha Akbary Moghaddam, Sandeep Acharya, Michaela Schwaiger-Haber, Shu Liao
| BioRxiv
Abstract Small molecules (SMs) are integral to biological processes, influencing metabolism, homeostasis, and regulatory networks. Despite their importance, a significant knowledge gap exists regarding their downstream effects on biological pathways and gene expression, largely due to differences in scale, variability, and noise between untargeted metabolomics and sequencing-based technologies.
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Novel Loci (EIF4A2, ADIPOQ, TPRG1) for Triglyceride / High-density Lipoprotein Cholesterol Ratio Longitudinal Change (ΔTHR) among Subjects without Type 2 Diabetes: Evidence from the Long Life Family Study (LLFS) and the Framingham Heart Study (FHS) Offspr

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By Lihua Wang, Siyu Wang, Jason A Anema, Vaha Akbary Moghaddam
| medRxiv
The authors have declared no competing interest. This research was supported by the National Institute on Aging of the National Institutes of Health (NIA/NIH) under U19AG063893. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Washington University in Saint Louis IRBS approved this study.
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