Vaidotas Kiseliovas

Abstract The development of a large variety of single-cell analytical methods has empowered researchers to explore diverse biological questions at the level of individual cells. Among these, droplet-based single-cell RNA sequencing (scRNA-seq) methods have been particularly prevalent owning to their high-throughput capabilities and reduced reaction volumes.

Ironing out a survival strategy Metastatic cells display a notable ability to adapt to—and even thrive in—harsh microenvironments. One extreme example is leptomeningeal metastases (LM), cancer cells that enter a region of the central nervous system called the subarachnoid space, which is filled with cerebral spinal fluid (CSF). This anatomic site has a limited supply of micronutrients such as iron, and it harbors immune cells. Chi et al.

Affiliations Program for Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA Manu Setty , Vaidotas Kiseliovas , Jacob Levine , Adam Gayoso , Linas Mazutis & Dana Pe’er Authors Search for Manu Setty in: Search for Vaidotas Kiseliovas in: Search for Jacob Levine in: Search for Adam Gayoso in: Search for Linas Mazutis in: Search for Dana Pe’er in: Corresponding author Correspondence to Dana Pe’er.