Valentin Cabanas Perianes on Muck Rack

Valentin Cabanas Perianes

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Articles

Intestinal Perforation Secondary to Bortezomib‐Induced Autonomic Neuropathy

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By Andrea Garcia, Andrea García, Estela Ruiz Ruiz, Eva Espejo, Valentin Cabanas Perianes
| Wiley Online Library Verified
1 Introduction Bortezomib (BTZ) is a proteasome inhibitor that prevents the breakdown of ubiquitinated proteins, causing their accumulation in the cytosol, which leads to cell cycle arrest and apoptosis. This drug was approved for the treatment of multiple myeloma (MM) in 2003 [1, 2], and since then, it has become part of the standard therapy for this disease, often in combination with other medications.
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