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Valentin Legras

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PBPK Modeling of Entrectinib and Its Active Metabolite to Derive Dose Adjustments in Pediatric Populations Co‐Administered with CYP3A4 Inhibitors

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By Kenichi Umehara, Neil J. Parrott, Emilie Schindler, Valentin Legras
| Wiley Online Library Verified
CONFLICT OF INTEREST The authors declared no competing interests for this work. Supporting Information Filename Description cpt3386-sup-0001-Supinfo.docxWord 2007 document , 1.5 MB Data S1. References 1 & Mechanisms of disease: oncogene addiction—a rationale for molecular targeting in cancer therapy. Nat. Clin. Pract. Oncol. 3, 448–457 (2006). 2 et al. Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1–2 trials. Lancet Oncol.
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