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Valentina Bardelli

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Articles

A specific stem cell program and CD112 immunological axis dysfunctions underpinning monosomy 7-associated myeloid neoplasms

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By Carlotta Nardelli, Martina Quintini, Valeria Di Battista, Valentina Pierini, Barbara Crescenzi, Fabrizia Pellanera, Caterina Matteucci, Giovanni Martino, Francesco Adamo, Francesca Milano, Maria Paola Martelli, Pietro Merli, Loredana Bury, Mattia Forcato, Franco Locatelli, Loredana Ruggeri, Cristina Mecucci, Valentina Bardelli, Maria Crocioni, Paolo Gorello
| Nature Verified
Abstract Monosomy 7 (−7) is occurring as isolated change or in complex karyotypes in 10–20% of myeloid neoplasms with poor prognosis. Although several genes mapping at chromosome 7 have been involved in pathogenetic mechanisms, the −7 molecular landscape is not fully elucidated. Using an epi-transcriptomic approach, new biological insights emerged in monosomy 7.
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