Valeria Uvarova

We all know the basics of healthy aging: eat well, do exercise and get enough sleep. However, research has revealed that aging is not simply a passive and inevitable decline. Rather, it is a process that can be delayed by targeting certain signaling pathways, such as the pathways that help the body respond and adapt to various forms of stress that might otherwise cause harm.

Abstract Stress responses are controlled by specialized stress-responsive proteostasis transcription factors that rapidly upregulate protein quality components to re-establish protein homeostasis and safeguard survival. Here we show that the zinc finger transcription factor PQM-1 is crucial for stress survival in response to thermal and oxidative challenges.