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Valerio Chiurchiù on Muck Rack

Valerio Chiurchiù

As seen in: Nature, Wiley Online Library, Frontiers, MDPI, Cell Metabolism, The Journal of Immunology
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Articles

The oxytocin system mediates behavioral and neurobiological alterations associated with early adversity - Molecular Psychiatry

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By Sebastian Luca D’Addario, Carlo Cifani, Massimiliano Renzi, Valerio Chiurchiù, Maria Teresa Viscomi, Gilda Chilà, Alice Passeri, Greta Massa
| Nature Verified
Abstract Early life adversities (ELA) can significantly impact brain development and adult behavior, potentially increasing vulnerability to psychopathologies. Evidence shows that ELA exposure is significantly associated with dysfunctional Oxytocin (OXT), a neuropeptide strongly engaged in social behavior and linked to the processing of rewarding stimuli, such as drugs of abuse.
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Nonmotor Symptoms Reduce Quality of Life in Parkinson′s Disease Depending on Disease Stage and Age at Onset

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By Roberta Bovenzi, Matteo Conti, Valerio Chiurchiù, Valentino De Franco
| Wiley Online Library Verified
1. Introduction Parkinson′s disease (PD) is a disabling neurodegenerative disorder characterized by the primary loss of dopaminergic nigral cells and a widespread accumulation of α-synuclein-containing Lewy bodies [1].
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MACanalyzeR scRNAseq analysis tool reveals PPARγHIGH/GDF15HIGH lipid-associated macrophages facilitate thermogenic expansion in BAT - Nature Communications

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By Loreana Sanches Silveira, Lorenzo Nevi, Paolo Grumati, Claudia Di Biagio, Giuseppe Rizzo, Valerio Chiurchiù, Stoyan Ivanov, Beiyan Zhou, Jesse Williams, Katia Aquilano
| Nature Verified
Abstract Macrophages are key regulators of adipose tissue plasticity. Obesity impairs brown adipose tissue (BAT) function in humans, yet macrophage-mediated mechanisms remain elusive. Here, we introduce MACanalyzeR, a single-cell RNA sequencing (scRNAseq) tool designed for comprehensive monocyte/macrophage metabolic profiling. Applying MACanalyzeR to BAT from obese male murine models (db/db and HFD-fed mice), we identify lipid-associated macrophages (LAMs) with foamy characteristics.
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