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Vallari Shukla

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Articles

Extensive enhancer crosstalk controls PPARG2 activation during adipogenesis

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By Mette Hyldahl, Hesam Dashti, Maria Stahl Madsen, Vallari Shukla, Esra Durmaz Mitchell, Alexander Rauch, Melina Claussnitzer, Susanne Mandrup, Anna Cetnarowska, Marcus Nygård, Bo Vagner Hansen, Laura Kristine Holm, Kaja Madsen
| Nature Verified
Abstract Transcriptional master regulators drive cell fate transitions. Peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipogenesis, and its expression must therefore be tightly regulated and efficiently induced in response to adipogenic cues. Here we decipher the regulatory mechanisms of the highly connected enhancer community driving activation of the PPARG locus during adipocyte differentiation of human mesenchymal stem cells.
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Chromosome errors in human eggs shape natural fertility over reproductive life span

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By Jennifer R. Gruhn, Vallari Shukla, Robert Blanshard
| Science Magazine Verified
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