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Articles

Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism?

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By van Baren, Mario R. O, BioEnergy Laboratory, van Hellemond
| portlandpress.com
Numerous human pathogens express AOX, the activity of which facilitates a number of vital functions in the pathogen adaptation processes, which in turn can enhance their pathogenicity. One example is in Trypanosoma brucei (a causative agent of trypanosomiasis), where AOX plays a crucial role in adapting the metabolism to facilitate its life-cycle either in the tsetse fly (genus Glossina) or within the human bloodstream.
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Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin

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By van Baren
| portlandpress.com
Skip Nav Destination Research Article| March 28 2022
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GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

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By Von den Hoff, Van Cutsem, van Baren
Combination chemotherapy is used in the treatment of most patients with advanced PDAC, yet the field is lacking robust biomarkers of outcome to guide regimen selection. Here, we show that patients with tumors of a modified “basal-like” phenotype, or those with low GATA6 RNA expression, have inferior outcomes compared with those with the “classical” phenotype. The latter are accurately identified by high GATA6 expression and positive GATA6 staining by ISH.
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