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Articles by van der Does
BioClock-optimizing Bright Light Therapy for adults with depression: a study protocol for a multicenter randomized clinical trial on treatment strategies, response predictors, and chronobiological and neurobiological mechanisms | Trials | Full Text
Personal light exposure will be evaluated using sensors developed by the Eindhoven University of Technology [88]. The light-related parameters for analysis may include logarithmic transformations of light level in lux illuminance (logEV) or melanopic equivalent daylight illuminance (mEDI) during specific periods, such as 1 h before EMA notifications, 3 h after waking, 3 h before bedtime, the interval between bedtime and wake time, and across the entire day.
Structure and function relationships of mucociliary clearance in human and rat airways - Nature Communications
Abstract Mucociliary clearance is a vital defense mechanism of the human airways, protecting against harmful particles and infections. When this process fails, it contributes to respiratory diseases like chronic obstructive pulmonary disease (COPD) and asthma. While advances in single-cell transcriptomics have revealed the complexity of airway composition, much of what we know about how airway structure impacts clearance relies on animal studies.
Summary: Homo, Hunter-Gatherer, Habermas: An Inquiry into Deliberation
Journal ID (publisher): PLC Title: Politics of the Low Countries Publisher: Eleven International Publishing (The Hague ) ISSN: 2589-9929 Publication date Created: December 2023 Volume: 5 Issue: 2 Pages: 212-214 (pp. 212-214) Article Publisher ID: PLC-D-23-00018 DOI: 10.5553/PLC/.000054 SO-VID: aa071fc7-89da-4dd0-a49f-715672f307c6
Acute cigarette smoke exposure leads to higher viral infection in human bronchial epithelial cultures by altering interferon, glycolysis and GDF15-related pathways | Respiratory Research | Full Text
To determine the effect of CS exposure on viral replication, we exposed ALI-PBEC derived from COPD and non-COPD donors to CS followed by RV-A16 infection. The experimental design is summarized in Additional file 1: Fig. S1. At 24 and 48 h post infection (hpi), intracellular viral RNA (vRNA) levels of RV-A16 were significantly increased in CS-exposed cultures when compared to air-exposed cultures (Fig. 1A and 1B). This effect was similar between COPD (red dots) and non-COPD donors (black dots) (Fig.
Airway epithelial cells mount an early response to mycobacterial infection
Introduction Tuberculosis (TB) is caused by the highly successful respiratory pathogen Mycobacterium tuberculosis (Mtb), which has infected approximately a quarter of the world population (Paulson, 2013). For decades, Mtb has been the leading cause of death from a single infectious agent, killing over 1.5 million people each year (Global tuberculosis report, 2022).
Omega-3 fatty acids influence mood in healthy and depressed individuals
Depression is a leading cause of disability in the United States,1 with lifetime prevalence rates of over 16%.2 Risk for developing depression is highest in the age ranges of 15 to 19 and 25 to 29 years.3 Major depressive disorder (MDD) accounts for over 60% of suicides, and is among the top ten most economically costly diseases in the United States.4 Despite pervasive antidepressant use,5 current pharmacological treatment options are only moderately more effective than placebo; i.e.,...
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