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Articles by Van Eijck
The impact of neoadjuvant therapy in patients with left-sided resectable pancreatic cancer: an international multicenter study
Rangelova, E. et al. (2024) The impact of neoadjuvant therapy in patients with left-sided resectable pancreatic cancer: an international multicenter study. Annals of Oncology, (doi: 10.1016/j.annonc.2024.12.015) (PMID:39814200) (Accepted for Publication) Text 345394.pdf - Accepted Version Available under License Creative Commons Attribution.
Evaluation of photoplethysmography-based monitoring of pulse rate, interbeat-intervals, and oxygen saturation during high-intensity interval training - BioMedical Engineering OnLine
Methods This study constituted a single-center, non-randomized interventional study involving healthy volunteers equipped with the Corsano CardioWatch 287–2 during HIIT. The study consisted of a single visit per participant and took place from January 2024 till March 2024 at the Hague Tech center (The Hague, the Netherlands).
Chemotherapy switch for localized pancreatic cancer: a systematic review and meta-analysis
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-associated mortality, with a 5-year survival of 13%1. Localized (that is non-metastatic) PDAC is classified as resectable, borderline resectable (BR), or locally advanced (LA), based on the extent of vascular contact2. The combination of systemic chemotherapy and surgical resection results in the best long-term survival3. Neoadjuvant and induction treatment has become the standard of care for patients with BR and LA PDAC.
Rintatolimod in Advanced Pancreatic Cancer enhances Anti-Tumor Immunity through Dendritic Cell-Mediated T Cell Responses
Purpose: Amid the need for new approaches to improve survival in pancreatic ductal adenocarcinoma (PDAC), immune-based therapies have garnered interest. Rintatolimod, a toll-like receptor 3 (TLR-3) agonist, is a potential candidate due to its dual impact on restraining PDAC cell functions and boosting the anti-tumor immune response. This study investigates the effect of TLR-3 activation through rintatolimod on the peripheral immune landscape of advanced PDAC patients.
Nationwide validation of the distal fistula risk score (D-FRS) - Langenbeck's Archives of Surgery
Abstract Distal pancreatectomy (DP) is associated with a high complication rate of 30–50% with postoperative pancreatic fistula (POPF) as a dominant contributor. Adequate risk estimation for POPF enables surgeons to use a tailor-made approach. Assessment of the risk of POPF prior to DP can lead to the application of preventive strategies. The current study aims to validate the recently published preoperative and intraoperative distal fistula risk score (D-FRS) in a nationwide cohort.
Perioperative or adjuvant mFOLFIRINOX for resectable pancreatic cancer (PREOPANC-3): study protocol for a multicenter randomized controlled trial - BMC Cancer
Trial design The PREOPANC-3 trial is an international, multicenter, phase 3, RCT initiated by the Dutch Pancreatic Cancer Group (DPCG). Patients with resectable pancreatic cancer are randomized to neoadjuvant mFOLFIRINOX followed by surgery and adjuvant mFOLFIRINOX (intervention; arm 1) or to surgery and adjuvant mFOLFIRINOX (comparator; arm 2) (Fig. 1).
Correction: Stereotactic ablative radiotherapy or best supportive care in patients with localized pancreatic cancer not receiving chemotherapy and surgery (PANCOSAR): a nationwide multicenter randomized controlled trial according to a TwiCs design (pdf) |
BMC Cancer, Jan 2023 This is a preview of a remote PDF: https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-023-10521-1 Doppenberg, D., Besselink, M. G., van Eijck, C. H. J., Intven, M. P. W., Groot Koerkamp, B., Kazemier, G., van Laarhoven, H. W. M., Meijerink, M., Molenaar, I. Q., Nuyttens, J. J. M. E., van Os, R., van Santvoort, H. C., van Tienhoven, G., Verkooijen, H. M., Versteijne, E., Wilmink, J. W., Lagerwaard, F. J., Bruynzeel, A. M. E.. , BMC Cancer, 2023, pp.
Correction: Stereotactic ablative radiotherapy or best supportive care in patients with localized pancreatic cancer not receiving chemotherapy and surgery (PANCOSAR): a nationwide multicenter randomized controlled trial according to a TwiCs design | BMC C
Authors and Affiliations Amsterdam UMC, Location Vrije Universiteit Amsterdam, Department of Radiation Oncology, Amsterdam, The Netherlands D. Doppenberg, R. van Os, G. van Tienhoven, E. Versteijne, F. J. Lagerwaard & A. M. E. Bruynzeel Amsterdam UMC, Location University of Amsterdam, Department of Surgery, Amsterdam, The Netherlands D. Doppenberg & M. G. Besselink Cancer Center Amsterdam, Amsterdam, The Netherlands D. Doppenberg, M. G. Besselink, G. Kazemier, H. W. M. van Laarhoven, M. Meijerink, G.
Long-term yield of pancreatic cancer surveillance in high-risk individuals
Discussion We prospectively investigated the long-term yield of pancreatic cancer surveillance in a large cohort of high-risk individuals. To date, this is the only published long-term surveillance programme that included both mutation carriers and FPC kindreds, of which all families have routinely undergone genetic counselling and testing and in which both EUS and MRI/MRCP were performed at every visit. Notably, participant and protocol adherence were exceptionally high.
Stereotactic ablative radiotherapy or best supportive care in patients with localized pancreatic cancer not receiving chemotherapy and surgery (PANCOSAR): a nationwide multicenter randomized controlled trial according to a TwiCs design (pdf) | Paperity
BMC Cancer, Dec 2022 This is a preview of a remote PDF: https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-022-10419-4 Doppenberg, D., Besselink, M. G., van Eijck, C. H. J., Intven, M. P. W., Koerkamp, B. Groot, Kazemier, G., van Laarhoven, H. W. M., Meijerink, M., Molenaar, I. Q., Nuyttens, J. J. M. E., van Os, R., van Santvoort, H. C., van Tienhoven, G., Verkooijen, H. M., Versteijne, E., Wilmink, J. W., Lagerwaard, F. J., Bruynzeel, A. M. E.. , BMC Cancer, 2022, pp.
Perioperative or adjuvant mFOLFIRINOX for resectable pancreatic cancer (PREOPANC-3): study protocol for a multicenter randomized controlled trial
BMC Cancer, Aug 2023 Surgical resection followed by adjuvant mFOLFIRINOX (5-fluorouracil with leucovorin, irinotecan, and oxaliplatin) is currently the standard of care for patients with resectable pancreatic cancer. The main concern regarding adjuvant chemotherapy is that only half of patients actually receive adjuvant treatment. Neoadjuvant chemotherapy, on the other hand, guarantees early systemic treatment and may increase chemotherapy use and thereby improve overall survival.
Silly requests by MH17 defense lawyers : hearing of author Koreandefense
by From November 3 to 5 2020 the defense lawyers of MH17 suspect Pulatov had the opportunity to request additional investigation as well as to request for interviews of witness and experts. And they sure took the opportunity. Many witness and experts were requested for an interview. In a serie of blogposts I will discuss these requests and point out many of the requests do not make any sense. Earlier I blogged about 25 silly remarks by the lawyers here.
Silly requests by MH17 defense lawyers : the Makiivka video
by From November 3 to 5 2020 the defense lawyers of MH17 suspect Pulatov had the opportunity to request additional investigation as well as to interview witness and experts. And they sure took the opportunity. Many witness and experts were requested for an interview. In a serie of blogposts I will discuss these requests and point out many of the requests do not make any sense. Earlier I blogged about 25 silly remarks by the lawyers here. In the first episode I will discuss the Makiivka video.
The seventh blind test of crystal structure prediction: structure generation methods
2.6. Pushing the boundaries: new features in this CSP blind test The seventh blind test presented new and relevant challenges to CSP methods, the key differences to previous blind tests being: (a) splitting the test into two parts; structure generation and structure ranking methods were assessed separately, the latter involving a standardized set of structures; (b) the analysis of larger sets of structures (up to 1500, compared to 100 in the sixth blind test); (c) the inclusion of challenging...
The seventh blind test of crystal structure prediction: structure generation methods
2.1. Motivation The decision to undertake a seventh blind test was driven by two key factors. Firstly, by 2018, it was clear that new methods were appearing in the literature, and feedback from the academic and industrial community indicated that a new test was desirable, as there had been sufficient methodological progress to justify a new test.
Silly remarks and nonsense requests by Dutch lawyers defending MH17 suspect Oleg Pulatov #12. Witness statement by native english speaker was correct
by During the plea by the Dutch lawyers Boudewijn Van Eijck and Sabine ten Doessschate while defending their client Oleg Pulatov many silly remarks and nonsense requests were made by these two Dutch lawyers. This post is part of a serie of blogposts showing these silly remarks made at June 22 and June 23. All blogposts on this topic can be read here. During the plea by Sabine ten Doessschate she stated that the dossier has parts which were not properly translated into english .
Silly remarks and nonsense requests by Dutch lawyers defending MH17 suspect Oleg Pulatov #4. A retired Mig 25 cannot have downed MH17
by During the plea by the Dutch lawyers Boudewijn Van Eijck and Sabine ten Doessschate while defending their client Oleg Pulatov many silly remarks and nonsense requests were made by these two Dutch lawyers. This post is part of a serie of blogposts showing these silly remarks made at June 22 and June 23. All blogposts on this topic can be read here. The lawyers suggest that a Mig 25 could have launched a missile towards MH17.
Frontiers | Gemcitabine-based neoadjuvant treatment in borderline resectable pancreatic ductal adenocarcinoma: a systematic review and meta-analysis of individual patient data | Oncology
Francesco Giovinazzo1, 2*, Fiammetta Soggiu3, Jin-Young Jang4, Eva Versteijne5, Geertjan Van Tienhoven5, Casper H. Van Eijck6, Youngmin Han4, Seong Ho Choi4, Chang M. Kang7, Mark M. Zalupski8, Hasham Ahmad9, Sarah Yentz8, Scott Helton10, J B.
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